Frova and Paracetamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Frova (frovatriptan succinate) and Paracetamol (acetaminophen). Common drug interactions include fatigue among females and joint swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Frova and Paracetamol. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Frova?

Frova has active ingredients of frovatriptan succinate. It is often used in migraine. eHealthMe is studying from 2,100 Frova users. Check the latest studies of Frova.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

45 people who take Frova and Paracetamol together, and have interactions are studied.

Frova and Paracetamol drug interactions.

What are the common drug interactions of Frova and Paracetamol, by gender? *:

female:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Gastric ulcer (stomach ulcer)
Heart rate irregular
Loss of consciousness
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dyspnoea (difficult or laboured respiration)
Drug ineffective
Panic attack
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

male:

Joint swelling
Peripheral swelling
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urinary retention (the inability to completely or partially empty the bladder)
Vomiting
Confusional state
Constipation
Drug withdrawal headache

What are the common drug interactions of Frova and Paracetamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Heart rate irregular
Loss of consciousness
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Dizziness
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Extrasystoles

30-39:

Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Eye pruritus (eye itching)
Urinary tract infection
Urticaria chronic (long lasting rash of round, red welts on the skin that itch intensely)
Fatigue (feeling of tiredness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Joint swelling
Peripheral swelling

40-49:

Gastric ulcer (stomach ulcer)
Drug withdrawal headache

50-59:

Asthenia (weakness)
Eye irritation
Eye pain
Gait disturbance
Infusion related reaction
Myalgia (muscle pain)
Tendonitis (a condition that causes pain and swelling of tendons)
Visual field defect
Abdominal pain
Anuria (failure of the kidneys to produce urine)

60+:

Abnormal weight gain
Anxiety
Panic attack
Sedation
Tremor (trembling or shaking movements in one or more parts of your body)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Confusional state
Constipation
Dry mouth
Hyperaesthesia

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 8.89%
Depression: 4 people, 8.89%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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