Frova and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Frova (frovatriptan succinate) and Protonix (pantoprazole sodium). Common drug interactions include chest pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Frova and Protonix. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Frova?

Frova has active ingredients of frovatriptan succinate. It is often used in migraine. eHealthMe is studying from 2,100 Frova users. Check the latest studies of Frova.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

81 people who take Frova and Protonix together, and have interactions are studied.

What are the common drug interactions of Frova and Protonix, by gender? *:

female:

Chest pain
Aggression
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Arthralgia (joint pain)
Diarrhoea haemorrhagic (bloody diarrhoea)
Sinusitis (inflammation of sinus)
Chronic kidney disease
Fatigue (feeling of tiredness)
Vomiting

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Secondary hyperthyroidism
Renal injury (kidney injury)

What are the common drug interactions of Frova and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder disorder
Pain
Pancreatitis (inflammation of pancreas)
Sphincter of oddi dysfunction (dysfunction of a muscular valve that controls the flow of digestive juices)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Dizziness
Feeding disorder (when children refuse to eat certain food groups)
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)

30-39:

Headache (pain in head)
Pain
Weight increased
Arthralgia (joint pain)
Chest pain
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Joint sprain (an injury to joint surrounding flexible fibres)
Nausea (feeling of having an urge to vomit)

40-49:

Panic attack
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Patellofemoral pain syndrome (pain in the front of the knee)
Polydipsia (excessive thirst)
Polyuria (production of too much dilute urine)
Psychomotor skills impaired
Temperature intolerance (inability to go in temperature)
Thyroid neoplasm (tumour of thyroid)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Weight increased

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood pressure increased
Abdominal pain upper
Aggression
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cataract (clouding of the lens inside the eye)
Drug ineffective
Erythema (redness of the skin)
Infection

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Leukopenia (less number of white blood cells in blood)
Oedema peripheral (superficial swelling)
Pain in extremity
Pruritus (severe itching of the skin)
Rash generalised (rash on most of body parts)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Secondary hyperthyroidism

What are the existing conditions these people have? *

Pain: 17 people, 20.99%
Immunodeficiency Common Variable: 12 people, 14.81%
Stress And Anxiety: 11 people, 13.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 13.58%
Depression: 10 people, 12.35%
Insomnia (sleeplessness): 10 people, 12.35%
Asthma: 10 people, 12.35%
High Blood Cholesterol: 9 people, 11.11%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 9.88%
Birth Control: 8 people, 9.88%

* Approximation only. Some reports may have incomplete information.

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