Gabapentin and Palladone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gabapentin (gabapentin) and Palladone (hydromorphone hydrochloride). Common drug interactions include impaired work ability among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Palladone. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,990 Gabapentin users. Check the latest studies of Gabapentin.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

28 people who take Gabapentin and Palladone together, and have interactions are studied.

Gabapentin and Palladone drug interactions.

What are the common drug interactions of Gabapentin and Palladone, by gender? *:

female:

Impaired work ability
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Nerve injury
Pancreatic enzyme abnormality
Peroneal nerve palsy
Surgery
Walking disability
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Activities of daily living impaired
Application site erythema (redness of the skin at application site)

male:

Drug dependence
Emotional distress
Acute abdomen
Adrenal mass
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic arteriosclerosis (hardening of the aortic arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebral arteriosclerosis (thickening and hardening of the walls of the arteries in the brain)
Confusional state
Death

What are the common drug interactions of Gabapentin and Palladone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Overdose
Anxiety
Depression
Drug dependence
Emotional distress
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Activities of daily living impaired
Application site erythema (redness of the skin at application site)
Application site hyperaesthesia (abnormal increase in sensitivity to stimuli of the sense at application site)

40-49:

Middle ear inflammation (infection of middle ear with pain and swelling)
Nasopharyngitis (inflammation of the nasopharynx)
Overdose
Pyrexia (fever)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Deafness unilateral
Drug dependence
Hypersensitivity
Hypertensive heart disease
Infection

50-59:

n/a

60+:

Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Emotional distress
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic arteriosclerosis (hardening of the aortic arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebral arteriosclerosis (thickening and hardening of the walls of the arteries in the brain)
Death
Dehydration (dryness resulting from the removal of water)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the existing conditions these people have? *

Pain: 12 people, 42.86%
Constipation: 4 people, 14.29%
Cancer Pain: 4 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 10.71%
Sleep Disorder: 2 people, 7.14%
Retching (strong involuntary effort to vomit): 2 people, 7.14%
Panic Disorder: 2 people, 7.14%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.14%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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