Gabapentin and Pirfenidone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gabapentin (gabapentin) and Pirfenidone (pirfenidone). Common drug interactions include insomnia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Pirfenidone. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,987 Gabapentin users. Check the latest studies of Gabapentin.

What is Pirfenidone?

Pirfenidone has active ingredients of pirfenidone. eHealthMe is studying from 2,648 Pirfenidone users. Check the latest studies of Pirfenidone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

41 people who take Gabapentin and Pirfenidone together, and have interactions are studied.

Gabapentin and Pirfenidone drug interactions.

What are the common drug interactions of Gabapentin and Pirfenidone, by gender? *:

female:

Insomnia (sleeplessness)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Lip swelling
Oxygen saturation decreased
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sputum discoloured
Urticaria (rash of round, red welts on the skin that itch intensely)

male:

Dyspnoea (difficult or laboured respiration)
Diarrhoea
Intestinal polyp (small growths in the bowel with the potential for further growth)
Lethargy (tiredness)
Lower respiratory tract infection
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sensory loss (senses loss)
Sepsis (a severe blood infection that can lead to organ failure and death)
Pneumonia

What are the common drug interactions of Gabapentin and Pirfenidone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Right ventricular failure (right half of the heart fails to work)
Sepsis (a severe blood infection that can lead to organ failure and death)

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cataract (clouding of the lens inside the eye)
Hypersomnia (excessive daytime sleepiness (eds))
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Nausea (feeling of having an urge to vomit)
Back pain
Chills (felling of cold)
Decreased appetite
Oropharyngeal pain
Pruritus (severe itching of the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Vomiting
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Diarrhoea
Abnormal dreams
Lethargy (tiredness)
Lower respiratory tract infection
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sensory loss (senses loss)
Sepsis (a severe blood infection that can lead to organ failure and death)
Pulmonary alveolar haemorrhage (acute bleeding)
Productive cough

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 21 people, 51.22%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 19.51%
Pain: 6 people, 14.63%
Back Pain: 4 people, 9.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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