Gaviscon and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gaviscon (aluminum hydroxide; magnesium trisilicate) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include myocardial infarction among females and myxoedema coma among males.

The phase IV clinical study analyzes what interactions people have when they take Gaviscon and Septra. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Gaviscon?

Gaviscon has active ingredients of aluminum hydroxide; magnesium trisilicate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 12,355 Gaviscon users. Check the latest studies of Gaviscon.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

14 people who take Gaviscon and Septra together, and have interactions are studied.

What are the common drug interactions of Gaviscon and Septra, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pruritus (severe itching of the skin)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

male:

Myxoedema coma (coma with long untreated hypothyroidism)
Hyperglycaemia (high blood sugar)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Gaviscon and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Middle ear disorder (disease of internal ear)
Middle ear effusion (fluid in middle ear)
Muscle contractions involuntary (uncontrolled muscle contraction)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Nasal septum deviation (deviated nasal septum)
Nausea (feeling of having an urge to vomit)
Nephritic syndrome (a collection of signs (known as a syndrome) associated with disorders affecting the kidneys, more specifically glomerular disorders)
Neuralgia (pain in one or more nerves)

50-59:

Anaemia (lack of blood)
Dry mouth
Plasma cell myeloma (cancer that begins in plasma cells)
Blood creatinine increased
Creatinine renal clearance decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Pyrexia (fever)

60+:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Upper respiratory tract infection
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Lower respiratory tract infection
Lung transplant
Blood lactate dehydrogenase increased
Myxoedema coma (coma with long untreated hypothyroidism)
Blood pressure inadequately controlled
Blood pressure increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 42.86%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 21.43%
Vitamin B12 Deficiency: 1 person, 7.14%
Sinusitis (inflammation of sinus): 1 person, 7.14%
Rashes (redness): 1 person, 7.14%
Pulmonary Congestion (congestion in the lungs): 1 person, 7.14%
Pain: 1 person, 7.14%
Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Impaired Gastric Emptying: 1 person, 7.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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