Gemcitabine and Keppra drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Gemcitabine (gemcitabine) and Keppra (levetiracetam). Common drug interactions include bacteraemia among females and death among males.
The phase IV clinical study analyzes what interactions people have when they take Gemcitabine and Keppra. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.
What is Gemcitabine?
Gemcitabine has active ingredients of gemcitabine. eHealthMe is studying from 31,337 Gemcitabine users. Check the latest studies of Gemcitabine.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
52 people who take Gemcitabine and Keppra together, and have interactions are studied.

What are the common drug interactions of Gemcitabine and Keppra, by gender? *:
female:
- Bacteraemia (presence of bacteria in the blood)
- Breath sounds
- Cell death
- Cerebral thrombosis (blood clot in brain)
- Chills (felling of cold)
- Decreased appetite
- Dehydration (dryness resulting from the removal of water)
- Diarrhoea
- Fear
- Gastritis (inflammation of stomach)
male:
- Death
- Anxiety
- Cardiac disorder
- Cellulitis (infection under the skin)
- Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
- Diarrhoea
- Diplopia (double vision)
- Fatigue (feeling of tiredness)
- Haemorrhage (bleeding)
- Headache (pain in head)
What are the common drug interactions of Gemcitabine and Keppra, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Diplopia (double vision)
- Discomfort
- Dyspepsia (indigestion)
- Dysphonia (speech disorder attributable to a disorder of phonation)
- Fatigue (feeling of tiredness)
- Furuncle (infection of the hair follicle)
- Gait disturbance
- Haemorrhage (bleeding)
- Headache (pain in head)
- Malignant neoplasm progression (cancer tumour came back)
40-49:
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Thrombocytopenia (decrease of platelets in blood)
- Anaemia (lack of blood)
- Cell death
- Chills (felling of cold)
- Death
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Hepatocellular injury (liver injury)
- Hyperhidrosis (abnormally increased sweating)
- Jaundice cholestatic
50-59:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Renal cell carcinoma (a kidney cancer)
- Anxiety
- Arthropathy
- Cardiac disorder
- Dyspnoea (difficult or laboured respiration)
- Mobility decreased (ability to move is reduced)
- Oedema peripheral (superficial swelling)
- Pain
- Respiratory disorder (respiratory disease)
60+:
- Anaemia (lack of blood)
- Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Weight decreased
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anxiety
- Blood pressure systolic increased
- Body temperature decreased
- Breath sounds
What are the existing conditions these people have? *
- Pain: 9 people, 17.31%
- Headache (pain in head): 8 people, 15.38%
- Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 7 people, 13.46%
- Stress And Anxiety: 7 people, 13.46%
- Constipation: 7 people, 13.46%
- Tumor: 6 people, 11.54%
- Anaemia (lack of blood): 6 people, 11.54%
- Neoplasm Malignant (cancer tumour): 6 people, 11.54%
- Nausea (feeling of having an urge to vomit): 6 people, 11.54%
- Brain Neoplasm Malignant (brain cancer tumour): 5 people, 9.62%
* Approximation only. Some reports may have incomplete information.
Do you take Gemcitabine and Keppra?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Gemcitabine (31,337 reports)
- Keppra (73,504 reports)
Browse all drug interactions of Gemcitabine and Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Gemcitabine:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Gemcitabine and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Alam, S., Illo, C., Ma, Y. T., & Punia, P. , "Gemcitabine-induced cardiotoxicity in patients receiving adjuvant chemotherapy for pancreatic cancer: a case series", Case reports in oncology, 2018 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Alam, S., Illo, C., Ma, Y. T., & Punia, P. , "Gemcitabine-induced cardiotoxicity in patients receiving adjuvant chemotherapy for pancreatic cancer: a case series", Case reports in oncology, 2018 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on gemcitabine and levetiracetam (the active ingredients of Gemcitabine and Keppra, respectively), and Gemcitabine and Keppra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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