Gemfibrozil and Clozaril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gemfibrozil (gemfibrozil) and Clozaril (clozapine). Common drug interactions include neuroleptic malignant syndrome among females and antipsychotic drug level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Gemfibrozil and Clozaril. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Gemfibrozil?

Gemfibrozil has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 18,213 Gemfibrozil users. Check the latest studies of Gemfibrozil.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

On Jul, 31, 2026

63 people who take Gemfibrozil and Clozaril together, and have interactions are studied.

Gemfibrozil and Clozaril drug interactions.

What are the common drug interactions of Gemfibrozil and Clozaril, by gender? *:

female:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Anaemia (lack of blood)
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Asthma
Brain damage
Cardiac failure congestive

male:

Antipsychotic drug level increased
Neutropenia (an abnormally low number of neutrophils)
Homicidal ideation (thoughts about human killing another human)
Persecutory delusion
Pyromania (irresistible urge to start fires)
Sleep disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Blood glucose increased
Iron deficiency anaemia
Type 2 diabetes mellitus

What are the common drug interactions of Gemfibrozil and Clozaril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Neutropenia (an abnormally low number of neutrophils)
Otitis media (inflammation of the middle ear)
Pneumonia
Pyrexia (fever)

20-29:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

30-39:

Homicidal ideation (thoughts about human killing another human)
Abnormal behaviour
Antipsychotic drug level increased
Delusion (a false belief or opinion)
Haematocrit decreased
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Malaise (a feeling of general discomfort or uneasiness)
Neutropenia (an abnormally low number of neutrophils)
Persecutory delusion

40-49:

Blood urea nitrogen/creatinine ratio decreased
Dyspnoea (difficult or laboured respiration)
Suicidal ideation
Temporal lobe epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe)
Vomiting
Ascites (accumulation of fluid in the abdominal cavity)
Diabetic complication
Diabetic foot
Diabetic foot infection
Hepatic failure (liver failure)

50-59:

Antipsychotic drug level increased
Cerebral atrophy (decrement in size of brain)
Blood glucose increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemoglobin decreased
Loss of consciousness
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Type 2 diabetes mellitus
Abnormal behaviour

60+:

Anaemia (lack of blood)
Brain damage
Psychotic disorder
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Suicide attempt
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vascular calcification (deposits of calcium in the blood vessels)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Transplant
Cerebral infarction (less blood supply to brain resulting tissue damage)

What are the existing conditions these people have? *

Depression: 10 people, 15.87%
Bipolar Disorder (mood disorder): 6 people, 9.52%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 7.94%
Psychotic Disorder: 5 people, 7.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.94%
Sleep Disorder: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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