Gemzar and Polaramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gemzar (gemcitabine hydrochloride) and Polaramine (dexchlorpheniramine maleate). Common drug interactions include deafness unilateral among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Gemzar and Polaramine. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Gemzar?

Gemzar has active ingredients of gemcitabine hydrochloride. It is often used in pancreatic carcinoma. eHealthMe is studying from 20,315 Gemzar users. Check the latest studies of Gemzar.

What is Polaramine?

Polaramine has active ingredients of dexchlorpheniramine maleate. It is often used in allergic rhinitis. eHealthMe is studying from 10,531 Polaramine users. Check the latest studies of Polaramine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

47 people who take Gemzar and Polaramine together, and have interactions are studied.

Gemzar and Polaramine drug interactions.

What are the common drug interactions of Gemzar and Polaramine, by gender? *:

female:

Deafness unilateral
Death
Delayed effects of radiation
Drug ineffective
Eye disorder
Facial palsy (paralysis of face nerve)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Forced expiratory volume decreased (decreased lung expired air volume)
Groin pain

male:

Pyrexia (fever)
Rash
Oedema (fluid collection in tissue)
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper respiratory tract inflammation
Uveitis (inflammation of the uvea)
Chills (felling of cold)
Cholangitis (infection of the bile duct)
Pancreatitis acute (sudden inflammation of pancreas)
Pneumonia

What are the common drug interactions of Gemzar and Polaramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Thrombocytopenia (decrease of platelets in blood)

40-49:

Hepatic enzyme increased
Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Rash
Throat tightness

50-59:

Rash
Retinal disorder (disease of retina)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Septic shock (shock due to blood infection)
Skin lesion
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Toxic skin eruption (skin breakdown due to toxic substance)
Transaminases increased
Tremor (trembling or shaking movements in one or more parts of your body)
Visual acuity reduced (reduced clearness of vision)

60+:

Dyspnoea (difficult or laboured respiration)
Rash
Mouth ulceration (mouth ulcers)
Oedema (fluid collection in tissue)
Sepsis (a severe blood infection that can lead to organ failure and death)
Upper respiratory tract inflammation
Uveitis (inflammation of the uvea)
Cholangitis (infection of the bile duct)
Dysphagia (a condition in which swallowing is difficult or painful)
Pneumonia

What are the existing conditions these people have? *

Breast Cancer: 7 people, 14.89%
Fever: 4 people, 8.51%
Bile Duct Cancer Stage Iv: 4 people, 8.51%
Ovarian Epithelial Cancer (cancer that begins in the cells on the surface of the ovary): 3 people, 6.38%
Ovarian Cancer (cancer of ovary): 3 people, 6.38%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 6.38%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Gemzar and Polaramine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously