Gengraf and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gengraf (cyclosporine) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include rash among females and oedema peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Gengraf and Bactrim. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Gengraf?

Gengraf has active ingredients of cyclosporine. eHealthMe is studying from 960 Gengraf users. Check the latest studies of Gengraf.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

42 people who take Gengraf and Bactrim together, and have interactions are studied.

What are the common drug interactions of Gengraf and Bactrim, by gender? *:

female:

Rash
Renal failure (kidney dysfunction)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Ammonia increased
Aphasia (damage to the parts of the brain that control language)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial sepsis
Band neutrophil percentage increased
Bk virus infection
Blood bilirubin increased

male:

Oedema peripheral (superficial swelling)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Arthralgia (joint pain)
Vomiting
Anaemia (lack of blood)
Axillary mass
Cellulitis (infection under the skin)
Deformity (disfigurement)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)

What are the common drug interactions of Gengraf and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Deformity (disfigurement)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Joint swelling
Mobility decreased (ability to move is reduced)
Myosclerosis (hardening of muscle tissue)

50-59:

Renal failure (kidney dysfunction)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Ammonia increased
Anaemia (lack of blood)
Aphasia (damage to the parts of the brain that control language)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial sepsis
Band neutrophil percentage increased
Blood bilirubin increased
Bradycardia (abnormally slow heart action)

60+:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Axillary mass
Cellulitis (infection under the skin)
Hypokalaemia (low potassium)
Oedema peripheral (superficial swelling)
Dyspnoea (difficult or laboured respiration)
Anuria (failure of the kidneys to produce urine)
Arthralgia (joint pain)
Death

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 14.29%
Nuclear Magnetic Resonance Imaging Brain: 3 people, 7.14%
Insomnia (sleeplessness): 3 people, 7.14%
Immunodeficiency Disorders: 3 people, 7.14%
High Blood Cholesterol: 3 people, 7.14%
Gout (uric acid crystals building up in the body): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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