Gleevec and Kytril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gleevec (imatinib mesylate) and Kytril (granisetron hydrochloride). Common drug interactions include polyuria among females and disease progression among males.

The phase IV clinical study analyzes what interactions people have when they take Gleevec and Kytril. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Gleevec?

Gleevec has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml). eHealthMe is studying from 35,415 Gleevec users. Check the latest studies of Gleevec.

What is Kytril?

Kytril has active ingredients of granisetron hydrochloride. eHealthMe is studying from 10,766 Kytril users. Check the latest studies of Kytril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

26 people who take Gleevec and Kytril together, and have interactions are studied.

What are the common drug interactions of Gleevec and Kytril, by gender? *:

female:

Polyuria (production of too much dilute urine)
Protein total decreased
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Tenderness (pain or discomfort when an affected area is touched)
Varicella virus test positive
Venoocclusive liver disease (small veins in the liver are obstructed)
Viral infection
Weight increased
White blood cell count decreased

male:

Disease progression
Platelet count decreased
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Renal impairment (severely reduced kidney function)
Weight decreased
Acute leukaemia (blood cancer)
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the common drug interactions of Gleevec and Kytril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Ataxia (loss of full control of bodily movements)
Blood creatinine increased
Diarrhoea
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Liver fatty (fat deposition of liver)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metastases to brain (cancer spreads to brain)

30-39:

n/a

40-49:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Swelling face
Tooth extraction
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain upper
Blood albumin decreased
Abscess (pus)
Blood bicarbonate decreased
Blood creatinine increased

50-59:

Disease progression
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Heart rate increased
Asthenia (weakness)

60+:

Platelet count decreased
Nausea (feeling of having an urge to vomit)
Disease progression
Electrocardiogram qrs complex prolonged
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Oedema peripheral (superficial swelling)
Urine output decreased
Weight increased
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 19.23%
Gastrointestinal Stromal Tumor: 4 people, 15.38%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 15.38%
Cancer Pain: 3 people, 11.54%
Infection: 2 people, 7.69%
Chronic Phase Chronic Myeloid Leukaemia (blood cancer): 2 people, 7.69%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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