Glipizide and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glipizide (glipizide) and Nucynta (tapentadol hydrochloride). Common drug interactions include cerebrovascular accident among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Glipizide and Nucynta. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Glipizide?

Glipizide has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 64,852 Glipizide users. Check the latest studies of Glipizide.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 08, 2026

47 people who take Glipizide and Nucynta together, and have interactions are studied.

Glipizide and Nucynta drug interactions.

What are the common drug interactions of Glipizide and Nucynta, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Haemorrhage (bleeding)
Renal failure (kidney dysfunction)
Urinary tract infection
Asthenia (weakness)
Cardiac failure congestive
Cystitis (inflammation of the wall of the bladder)

male:

Dyspnoea (difficult or laboured respiration)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Abdominal pain
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Aphonia (inability to produce voice)
Arthralgia (joint pain)
Asthenia (weakness)
Chest discomfort
Chest pain

What are the common drug interactions of Glipizide and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Renal failure (kidney dysfunction)
Blood pressure increased
Cardiac flutter (abnormal heart rhythm)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Dyspnoea (difficult or laboured respiration)
Eye pain
Fall
Joint swelling

50-59:

Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Dyspnoea (difficult or laboured respiration)
Feeling drunk
Gait disturbance
Cyst (a closed sac)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Renal injury (kidney injury)
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Abdominal pain
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Back Pain: 11 people, 23.40%
High Blood Cholesterol: 10 people, 21.28%
Herniated Nucleus Pulposus (Slipped Disk): 9 people, 19.15%
High Blood Pressure: 9 people, 19.15%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 9 people, 19.15%
Depression: 7 people, 14.89%
Type 2 Diabetes: 7 people, 14.89%
Neuralgia (pain in one or more nerves): 5 people, 10.64%
Stress And Anxiety: 5 people, 10.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.64%

* Approximation only. Some reports may have incomplete information.

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