Glipizide and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glipizide (glipizide) and Tykerb (lapatinib ditosylate). Common drug interactions include device related infection among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Glipizide and Tykerb. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Glipizide?

Glipizide has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 64,852 Glipizide users. Check the latest studies of Glipizide.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Aug, 01, 2026

30 people who take Glipizide and Tykerb together, and have interactions are studied.

What are the common drug interactions of Glipizide and Tykerb, by gender? *:

female:

Device related infection
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Electrolyte imbalance
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic steatosis (fatty liver disease)

male:

Death
Pneumonia
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
C-reactive protein increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Glipizide and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Adnexa uteri mass (ovarian cysts)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Back pain
Blood creatine phosphokinase mb increased
Bone disorder
C-reactive protein increased
Constipation

40-49:

Diarrhoea
Dizziness
Dyspepsia (indigestion)
Local swelling (swelling at the site of some application of substance or injury)
Nausea (feeling of having an urge to vomit)
Rash pruritic (redness with itching)
Skin chapped
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Gingival bleeding (bleeding gums)
Headache (pain in head)
Ill-defined disorder
Insomnia (sleeplessness)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Hypoaesthesia (reduced sense of touch or sensation)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Back pain
Blood creatine phosphokinase mb increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
C-reactive protein increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 6 people, 20.00%
Meningioma Malignant (cancerous tumour of membranes that cover the brain and spinal cord just inside the skull): 2 people, 6.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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