Glucosamine and Vivelle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucosamine (glucosamine) and Vivelle (estradiol). Common drug interactions include abdominal pain upper among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Glucosamine and Vivelle. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Glucosamine?

Glucosamine has active ingredients of glucosamine. It is often used in joint pain. eHealthMe is studying from 15,547 Glucosamine users. Check the latest studies of Glucosamine.

What is Vivelle?

Vivelle has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,624 Vivelle users. Check the latest studies of Vivelle.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

30 people who take Glucosamine and Vivelle together, and have interactions are studied.

Glucosamine and Vivelle drug interactions.

What are the common drug interactions of Glucosamine and Vivelle, by gender? *:

female:

  1. Abdominal pain upper
  2. Anaemia (lack of blood)
  3. Back pain
  4. Depression
  5. Drug ineffective
  6. Foot fracture
  7. Nausea (feeling of having an urge to vomit)
  8. Pain in extremity
  9. Thirst
  10. Injection site rash

male:

  1. Abdominal pain upper
  2. Abscess (pus)
  3. Bronchopleural fistula
  4. Bunion (a painful swelling on the first joint of the big toe)
  5. Cancer pain
  6. Cardiomegaly (increased size of heart than normal)
  7. Cerebrovascular disorder (disease of brain)
  8. Cervical spinal stenosis (narrowing of the spinal canal in the neck)
  9. Chest pain
  10. Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)

What are the common drug interactions of Glucosamine and Vivelle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal pain upper
  2. Back pain
  3. Fatigue (feeling of tiredness)
  4. Hunger
  5. Hyperchlorhydria (gastric acid levels are higher in stomach)
  6. Pain in extremity
  7. Peripheral swelling
  8. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  9. Thirst

50-59:

  1. Sinusitis (inflammation of sinus)
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Spinal osteoarthritis (joint cartilage loss in spine)
  4. Tenderness (pain or discomfort when an affected area is touched)
  5. Tendon rupture (tear of tendon)
  6. Tendonitis (a condition that causes pain and swelling of tendons)
  7. Thoracic vertebral fracture
  8. Tibia fracture (fracture of lower leg bone)
  9. Tooth disorder (tooth disease)
  10. Tooth fracture

60+:

  1. Anaemia (lack of blood)
  2. Bone density decreased
  3. Hypertrichosis (hair growth on the body in an amount considered abnormal)
  4. Injection site erythema (redness at injection site)
  5. Injection site papule (solid pimple or swelling at injection site)
  6. Injection site pruritus (severe itching at injection site)
  7. Injection site rash
  8. Injection site warmth
  9. Muscle spasms (muscle contraction)
  10. Pain in extremity

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 23.33%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.67%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.67%
  4. High Blood Cholesterol: 4 people, 13.33%
  5. Osteoporosis (bones weak and more likely to break): 3 people, 10.00%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Glucosamine and Vivelle?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Glucosamine and Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucosamine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucosamine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vivelle and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on glucosamine and estradiol (the active ingredients of Glucosamine and Vivelle, respectively), and Glucosamine and Vivelle (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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