Glucotrol xl and Metoclopramide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucotrol xl (glipizide) and Metoclopramide (metoclopramide hydrochloride). Common drug interactions include pneumonia among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Glucotrol xl and Metoclopramide. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Glucotrol xl?

Glucotrol xl has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 6,863 Glucotrol xl users. Check the latest studies of Glucotrol xl.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.



On Jul, 11, 2026

29 people who take Glucotrol xl and Metoclopramide together, and have interactions are studied.

Glucotrol xl and Metoclopramide drug interactions.

What are the common drug interactions of Glucotrol Xl and Metoclopramide, by gender? *:

female:

  1. Pneumonia
  2. Weight increased
  3. Alopecia (absence of hair from areas of the body)
  4. Asthenia (weakness)
  5. Coma (state of unconsciousness lasting more than six hours)
  6. Cough
  7. Depression
  8. Drug ineffective
  9. Dyspnoea (difficult or laboured respiration)
  10. Fatigue (feeling of tiredness)

male:

  1. Pneumonia
  2. Pleural effusion (water on the lungs)
  3. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  4. Hypertension (high blood pressure)
  5. Hypokalaemia (low potassium)
  6. Hypotension (abnormally low blood pressure)
  7. Nail disorder (disease of nail)
  8. Neck pain
  9. Otitis externa (external ear infection)
  10. Otitis media (inflammation of the middle ear)

What are the common drug interactions of Glucotrol Xl and Metoclopramide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Pleural effusion (water on the lungs)
  2. Oedema lower limb (fluid collection in tissue of lower leg)
  3. Cardiomegaly (increased size of heart than normal)
  4. Hypotension (abnormally low blood pressure)
  5. Pneumonia
  6. Aortic atherosclerosis (degenerative process of aortic arteries)
  7. Atelectasis (partial or complete collapse of the lung)
  8. Blood sodium decreased
  9. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  10. Extrasystoles

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Aortic valve calcification
  3. Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
  4. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  5. Cardiac enzymes increased
  6. Cardiac murmur (an heart sound in valve abnormality)
  7. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  8. Contusion (a type of hematoma of tissue in which capillaries)
  9. Cough
  10. Depressed mood

50-59:

  1. Acne (skin problems that cause pimples)

60+:

  1. Diabetes mellitus inadequate control
  2. Pneumonia
  3. Otitis externa (external ear infection)
  4. Otitis media (inflammation of the middle ear)
  5. Tremor (trembling or shaking movements in one or more parts of your body)
  6. Vertigo
  7. Hypertension (high blood pressure)
  8. Sinusitis (inflammation of sinus)
  9. Death
  10. Regurgitation (expulsion of material)

What are the existing conditions these people have? *

  1. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 4 people, 13.79%
  2. Oedema (fluid collection in tissue): 4 people, 13.79%
  3. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 4 people, 13.79%
  4. Essential Hypertension (primary hypertension): 4 people, 13.79%
  5. Dysthymia (mild chronic depression): 4 people, 13.79%
  6. Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 4 people, 13.79%
  7. Cough: 4 people, 13.79%
  8. Pain: 3 people, 10.34%
  9. Ill-Defined Disorder: 3 people, 10.34%
  10. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Glucotrol xl and Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucotrol xl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucotrol xl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metoclopramide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on glipizide and metoclopramide hydrochloride (the active ingredients of Glucotrol xl and Metoclopramide, respectively), and Glucotrol xl and Metoclopramide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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