Glucovance and Namenda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucovance (glyburide; metformin hydrochloride) and Namenda (memantine hydrochloride). Common drug interactions include respiratory distress among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Glucovance and Namenda. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Namenda?

Namenda has active ingredients of memantine hydrochloride. It is often used in dementia. eHealthMe is studying from 14,283 Namenda users. Check the latest studies of Namenda.

On Jul, 31, 2026

18 people who take Glucovance and Namenda together, and have interactions are studied.

Glucovance and Namenda drug interactions.

What are the common drug interactions of Glucovance and Namenda, by gender? *:

female:

Respiratory distress (difficulty in breathing)
Tricuspid valve incompetence (inefficient heart valve)
Urinary retention (the inability to completely or partially empty the bladder)
Weight increased
Blood amylase increased
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Dizziness
Gastritis (inflammation of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Hypersensitivity

male:

Fall
Rib fracture
Fatigue (feeling of tiredness)
Gait disturbance
Heart rate irregular
Hip fracture
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Glucovance and Namenda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Confusional state
Rib fracture
Renal failure acute (rapid kidney dysfunction)
Asthenia (weakness)
Cardiac disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fatigue (feeling of tiredness)
Gait disturbance
Heart rate irregular

What are the existing conditions these people have? *

High Blood Cholesterol: 7 people, 38.89%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 4 people, 22.22%
Heart Rate Irregular: 3 people, 16.67%
Pain: 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Vitamin B Complex Deficiency: 1 person, 5.56%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 5.56%
Gastritis (inflammation of stomach): 1 person, 5.56%
Headache (pain in head): 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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