Glucovance and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucovance (glyburide; metformin hydrochloride) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include hyponatraemia among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Glucovance and Spiriva. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 14, 2026

62 people who take Glucovance and Spiriva together, and have interactions are studied.

Glucovance and Spiriva drug interactions.

What are the common drug interactions of Glucovance and Spiriva, by gender? *:

female:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)
Lung disorder (lung disease)
Mitral valve incompetence (inefficient heart valve)
Pain
Pneumonia
Respiratory distress (difficulty in breathing)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Wheezing (a high-pitched whistling sound made while you breath)
Arthralgia (joint pain)

male:

Cardiac failure congestive
Oedema peripheral (superficial swelling)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diabetes mellitus inadequate control
Gait disturbance
Pericarditis (inflammation of the pericardium)
Pulmonary hilum mass (lung cancer)
Pulse absent
Speech disorder
Arteriosclerosis (thickening and hardening of arteries)

What are the common drug interactions of Glucovance and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory failure
Anaemia (lack of blood)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Burning sensation
Chronic respiratory failure
Colonic polyp (extra part of colon tissue grow in intestine)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness

40-49:

Cholecystitis chronic (long lasting infection of gallbladder)
Pancreatitis acute (sudden inflammation of pancreas)

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomyopathy (weakening of the heart muscle)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Angioplasty
Diabetic nephropathy (diabetic kidney disease)
Injury
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Renal failure chronic (long lasting kidney dysfunction)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety

60+:

Back pain
Chronic kidney disease
Carbohydrate antigen 19-9 increased
Cardiac failure congestive
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Hyperglycaemia (high blood sugar)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)
Lung disorder (lung disease)

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 14.52%
High Blood Pressure: 7 people, 11.29%
Type 2 Diabetes: 6 people, 9.68%
Pain: 6 people, 9.68%
Depression: 6 people, 9.68%
Cardiac Disorder: 6 people, 9.68%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.06%
Dyspnea (difficult or laboured breathing): 5 people, 8.06%
Asthma: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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