Glucovance and Tradjenta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glucovance (glyburide; metformin hydrochloride) and Tradjenta (linagliptin). Common drug interactions include renal failure among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Glucovance and Tradjenta. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Tradjenta?

Tradjenta has active ingredients of linagliptin. It is often used in diabetes. eHealthMe is studying from 9,987 Tradjenta users. Check the latest studies of Tradjenta.

On Aug, 01, 2026

31 people who take Glucovance and Tradjenta together, and have interactions are studied.

Glucovance and Tradjenta drug interactions.

What are the common drug interactions of Glucovance and Tradjenta, by gender? *:

female:

Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Breast cancer
Ejection fraction decreased (systolic heart failure)
Feeling hot
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Oropharyngeal pain
Blood glucose decreased

male:

Chronic kidney disease
Drug ineffective
Pancreatitis (inflammation of pancreas)
Swollen tongue (swelling of tongue)
Death
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

What are the common drug interactions of Glucovance and Tradjenta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac arrest
Dysgeusia (disorder of the sense of taste)
Ear discomfort
Eye discharge
Eye pruritus (eye itching)
Feeling hot
Hunger
Hyperhidrosis (abnormally increased sweating)
Migraine (headache)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Feeling hot
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Oropharyngeal pain
Peripheral swelling
Purpura (purplish discoloration of the skin)
Rhinorrhoea (watery mucus discharge from the nose)
Skin disorder (skin disease)

60+:

Chronic kidney disease
Drug ineffective
Death
Dizziness
Hypoglycaemia (deficiency of glucose in the bloodstream)
Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the existing conditions these people have? *

High Blood Cholesterol: 12 people, 38.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 38.71%
Type 2 Diabetes: 11 people, 35.48%
High Blood Pressure: 11 people, 35.48%
Pain: 9 people, 29.03%
Stress And Anxiety: 8 people, 25.81%
Rashes (redness): 7 people, 22.58%
Gastric Ulcer (stomach ulcer): 7 people, 22.58%
Blood Magnesium Decreased: 7 people, 22.58%
Blood Iron Decreased: 7 people, 22.58%

* Approximation only. Some reports may have incomplete information.

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