Glycopyrrolate and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glycopyrrolate (glycopyrrolate) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include injury among females and sleep apnoea syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Glycopyrrolate and Hydroxyzine. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Glycopyrrolate?

Glycopyrrolate has active ingredients of glycopyrrolate. It is often used in hyperhidrosis. eHealthMe is studying from 5,599 Glycopyrrolate users. Check the latest studies of Glycopyrrolate.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 06, 2026

84 people who take Glycopyrrolate and Hydroxyzine together, and have interactions are studied.

Glycopyrrolate and Hydroxyzine drug interactions.

What are the common drug interactions of Glycopyrrolate and Hydroxyzine, by gender? *:

female:

Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myeloproliferative disorder (a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets)
Nephrolithiasis (calculi in the kidneys)
Oesophageal stenosis (narrowing of oesophagus)
Osteomyelitis (infection of bone)
Osteoporosis (bones weak and more likely to break)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Rectal prolapse (falling of rectum from normal place)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

male:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abnormal behaviour
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abdominal discomfort
Abdominal distension
Alanine aminotransferase increased
Anaemia (lack of blood)

What are the common drug interactions of Glycopyrrolate and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Colitis ulcerative (inflammation of colon with ulcer)
Haematochezia (passage of stools containing blood)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neurodegenerative disorder (progressive loss of structure or function of neurons and death of neuron)
Weight increased

10-19:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Galactorrhoea (secretion of breast milk in men)
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)

20-29:

Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate decreased
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Photophobia (extreme sensitivity to light)

30-39:

Paralysis

40-49:

Abdominal distension
Nausea (feeling of having an urge to vomit)
Papillary thyroid cancer
Vomiting
Aphasia (damage to the parts of the brain that control language)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Death
Decreased appetite
Lethargy (tiredness)
Memory impairment

50-59:

Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Influenza
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site pain
Joint injury
Lethargy (tiredness)
Limb injury
Migraine (headache)
Myalgia (muscle pain)

60+:

Pneumonia
Renal failure (kidney dysfunction)
Atelectasis (partial or complete collapse of the lung)
Biliary dilatation
Blindness transient (sudden loss of vision)
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Chest pain
Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

Pain: 33 people, 39.29%
High Blood Pressure: 25 people, 29.76%
Depression: 22 people, 26.19%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 17 people, 20.24%
Constipation: 13 people, 15.48%
Nausea (feeling of having an urge to vomit): 12 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 11.90%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 10.71%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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