Golytely and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Golytely (polyethylene glycol 3350; potassium chloride; sodium bicarbonate; sodium chloride; sodium sulfate, anhydrous) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include gastrointestinal disorder among females and renal tubular necrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Golytely and Zosyn. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Golytely?

Golytely has active ingredients of polyethylene glycol 3350; potassium chloride; sodium bicarbonate; sodium chloride; sodium sulfate, anhydrous. eHealthMe is studying from 907 Golytely users. Check the latest studies of Golytely.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

14 people who take Golytely and Zosyn together, and have interactions are studied.

What are the common drug interactions of Golytely and Zosyn, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemorrhage (bleeding)
Hypersomnia (excessive daytime sleepiness (eds))
Mycobacterial infection
Nausea (feeling of having an urge to vomit)
Neck pain
Night sweats (sweating in night)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Panic attack
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

male:

Renal tubular necrosis (death of kidney tubules)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Alcohol poisoning
Alcoholic liver disease
Anaemia (lack of blood)
Anxiety

What are the common drug interactions of Golytely and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Back pain
Constipation
Cough
Decreased interest
Depressed mood
Feeling drunk
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypersomnia (excessive daytime sleepiness (eds))
Mycobacterial infection

40-49:

Abscess (pus)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Abscess (pus)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Chronic kidney disease
Groin abscess (pus in groin)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Scrotal abscess (pus in scrotum)

60+:

Syncope (loss of consciousness with an inability to maintain postural tone)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mobility decreased (ability to move is reduced)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)
Hypertension (high blood pressure)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Respiratory failure (inadequate gas exchange by the respiratory system)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 50.00%
Pain: 6 people, 42.86%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 35.71%
Stress And Anxiety: 5 people, 35.71%
Constipation: 5 people, 35.71%
Diabetes: 5 people, 35.71%
Leukopenia (less number of white blood cells in blood): 5 people, 35.71%
Anaemia (lack of blood): 3 people, 21.43%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 14.29%
Hypotension (abnormally low blood pressure): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Golytely and Zosyn?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously