Gralise and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gralise (gabapentin) and Zide (hydrochlorothiazide). Common drug interactions include cough among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Gralise and Zide. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Gralise?

Gralise has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 4,282 Gralise users. Check the latest studies of Gralise.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

73 people who take Gralise and Zide together, and have interactions are studied.

What are the common drug interactions of Gralise and Zide, by gender? *:

female:

Cough
Nasopharyngitis (inflammation of the nasopharynx)
Eye irritation
Dizziness
Gastritis (inflammation of stomach)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Neuropathy peripheral (surface nerve damage)
Breast cancer recurrent
Breast cancer stage iv
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Arthralgia (joint pain)
Burning sensation
Red blood cell count decreased
Weight decreased
White blood cell count decreased
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Foreign body sensation in eyes (feeling of something in eye)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Gralise and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Somnolence (a state of near-sleep, a strong desire for sleep)
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Pyelonephritis (inflammation of kidney caused by bacteria)
Vomiting

40-49:

Foot fracture
Peripheral swelling
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Arthropathy
Balance disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dry mouth

50-59:

Dry mouth
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Facial paralysis (loss of function of face muscle)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Immune system disorder
Infusion site bruising
Injection site pain
Muscle spasms (muscle contraction)

60+:

Fall
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Haemoglobin decreased
Influenza
Lymphocyte count decreased
Mean cell volume increased (more than normal average red blood cell volume)
Pyrexia (fever)
Red blood cell count decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 20.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 15.07%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 13.70%
Immunodeficiency Common Variable: 7 people, 9.59%
Sleep Disorder: 5 people, 6.85%
Pain: 5 people, 6.85%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.85%
High Blood Cholesterol: 5 people, 6.85%
Type 2 Diabetes: 4 people, 5.48%
Drowsiness: 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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