Gravol and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gravol (dimenhydrinate) and Adcirca (tadalafil). Common drug interactions include haemorrhoidal haemorrhage among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Gravol and Adcirca. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Gravol?

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. eHealthMe is studying from 7,192 Gravol users. Check the latest studies of Gravol.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 25, 2026

36 people who take Gravol and Adcirca together, and have interactions are studied.

What are the common drug interactions of Gravol and Adcirca, by gender? *:

female:

Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Sinusitis (inflammation of sinus)
Hypotension (abnormally low blood pressure)
Blood pressure decreased
Eye swelling
Nasal discomfort
Pneumonia
Pyrexia (fever)

male:

Death
Decreased appetite
Irritability
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

What are the common drug interactions of Gravol and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arrhythmia (irregular heartbeat)
Drug hypersensitivity
Lethargy (tiredness)
Migraine (headache)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Visual impairment

30-39:

Abdominal pain upper
Asthenia (weakness)
Dizziness
Drug intolerance (drug sensitivity)
Fatigue (feeling of tiredness)
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Sinusitis (inflammation of sinus)
Blood pressure decreased

40-49:

Dyspnoea (difficult or laboured respiration)
Eye swelling
Hypotension (abnormally low blood pressure)
Nasal discomfort
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Hospitalisation
Pneumonia
Catheter site infection (infection at the site of insertion)
Lower respiratory tract infection

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Death
Abdominal pain upper
Ankle fracture
Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Device dislocation
Dyspnoea exertional (breathlessness or shortness of breath)
Fall
Haemoglobin decreased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 33 people, 91.67%
Ventricular Dysfunction (heart dysfunction): 5 people, 13.89%
Pain: 5 people, 13.89%
Oedema Peripheral (superficial swelling): 5 people, 13.89%
Oedema (fluid collection in tissue): 5 people, 13.89%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 5 people, 13.89%
Hypokalemia (low potassium): 5 people, 13.89%
Hypersensitivity: 5 people, 13.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 13.89%
Dyspnea (difficult or laboured breathing): 5 people, 13.89%

* Approximation only. Some reports may have incomplete information.

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