Guaifenesin and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Guaifenesin (guaifenesin) and Caffeine (caffeine). Common drug interactions include bacteraemia among females and immune system disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Guaifenesin and Caffeine. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Guaifenesin?

Guaifenesin has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 12,106 Guaifenesin users. Check the latest studies of Guaifenesin.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

43 people who take Guaifenesin and Caffeine together, and have interactions are studied.

Guaifenesin and Caffeine drug interactions.

What are the common drug interactions of Guaifenesin and Caffeine, by gender? *:

female:

Bacteraemia (presence of bacteria in the blood)
Device failure
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Small intestinal obstruction (blockage in small intestine)
Coma (state of unconsciousness lasting more than six hours)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Vomiting
Abdominal pain
Depressed level of consciousness

male:

Immune system disorder
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Rash
Alkalosis
Altered state of consciousness (altered state of mind)
Blood creatine phosphokinase increased
Cardiac arrest
Cardiac failure
Death
Developmental delay

What are the common drug interactions of Guaifenesin and Caffeine, by age (0-1 to 60+)? *:

0-1:

Developmental delay
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

n/a

20-29:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fall
Injury
Alkalosis
Altered state of consciousness (altered state of mind)
Blood creatine phosphokinase increased
Haematuria (presence of blood in urine)
Ketonuria (ketones in urine)
Nausea (feeling of having an urge to vomit)
Overdose

30-39:

Coma (state of unconsciousness lasting more than six hours)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Vomiting
Depressed level of consciousness
Anion gap increased
Blood lactic acid increased
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)

40-49:

Immune system disorder
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Eye infection
Migraine (headache)
Chronic kidney disease
Meibomian gland dysfunction (dry eyes)
Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Completed suicide (act of taking one's own life)

50-59:

Dyskinesia (abnormality or impairment of voluntary movement)
Loss of consciousness
Migraine (headache)

60+:

Bacteraemia (presence of bacteria in the blood)
Device failure
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug abuse
Drug ineffective
Overdose
Psoriasis (immune-mediated disease that affects the skin)
Pulmonary mass
Rash

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 20.93%
Insomnia (sleeplessness): 8 people, 18.60%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 8 people, 18.60%
Rashes (redness): 7 people, 16.28%
Constipation: 7 people, 16.28%
Itching: 7 people, 16.28%
Pain: 6 people, 13.95%
Asthma: 6 people, 13.95%
Headache (pain in head): 6 people, 13.95%
Diarrhea: 5 people, 11.63%

* Approximation only. Some reports may have incomplete information.

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