Harvoni and Thiamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Harvoni (ledipasvir; sofosbuvir) and Thiamine (thiamine (vitamin b1)). Common drug interactions include haemorrhage intracranial among females and hepatic encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Harvoni and Thiamine. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Harvoni?

Harvoni has active ingredients of ledipasvir; sofosbuvir. eHealthMe is studying from 19,858 Harvoni users. Check the latest studies of Harvoni.

What is Thiamine?

Thiamine has active ingredients of thiamine (vitamin b1). eHealthMe is studying from 11,036 Thiamine users. Check the latest studies of Thiamine.

On Jul, 12, 2026

50 people who take Harvoni and Thiamine together, and have interactions are studied.

What are the common drug interactions of Harvoni and Thiamine, by gender? *:

female:

Haemorrhage intracranial (bleeding within the skull)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Pleural effusion (water on the lungs)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)

male:

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Urinary tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asterixis (flapping tremor, or liver flap)
Asthenia (weakness)
Blood creatinine increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dementia (madness)
Dizziness

What are the common drug interactions of Harvoni and Thiamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Confusional state
Genotype drug resistance test positive
Hepatitis c
Insomnia (sleeplessness)
Vomiting

40-49:

Pruritus (severe itching of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Encephalopathy (functioning of the brain is affected by some agent or condition)

50-59:

Disease complication
Haemorrhage (bleeding)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Infection
Dizziness
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)

60+:

Urinary tract infection
Blood phosphorus decreased
Dementia (madness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gout (uric acid crystals building up in the body)
Haematuria (presence of blood in urine)
Incontinence (lack of moderation or self-control)
Lower respiratory tract infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Ascites (accumulation of fluid in the abdominal cavity)

What are the existing conditions these people have? *

Hepatitis C: 30 people, 60.00%
Hiv Infection: 9 people, 18.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 6.00%
Anaemia (lack of blood): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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