Harvoni and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Harvoni (ledipasvir; sofosbuvir) and Zestril (lisinopril). Common drug interactions include headache among females and face oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Harvoni and Zestril. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Harvoni?

Harvoni has active ingredients of ledipasvir; sofosbuvir. eHealthMe is studying from 19,858 Harvoni users. Check the latest studies of Harvoni.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Aug, 05, 2026

14 people who take Harvoni and Zestril together, and have interactions are studied.

What are the common drug interactions of Harvoni and Zestril, by gender? *:

female:

Headache (pain in head)
Hyperacusis (disorder in loudness perception)
Photophobia (extreme sensitivity to light)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Overdose
Thrombocytopenia (decrease of platelets in blood)
Asthma
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Face oedema (swelling of face)
Haemoglobin decreased
Palatal disorder
Palatal oedema (excessive accumulation of watery fluid in the roof of the mouth)
Rash
Rash generalised (rash on most of body parts)
Laryngeal oedema (swelling of larynx)
Respiratory failure (inadequate gas exchange by the respiratory system)
Tongue oedema (swelling of tongue)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Harvoni and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Face oedema (swelling of face)
Laryngeal oedema (swelling of larynx)
Respiratory failure (inadequate gas exchange by the respiratory system)
Tongue oedema (swelling of tongue)
Asthma
Palatal disorder
Palatal oedema (excessive accumulation of watery fluid in the roof of the mouth)

50-59:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Thrombocytopenia (decrease of platelets in blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

60+:

Haemoglobin decreased
Headache (pain in head)
Rash
Rash generalised (rash on most of body parts)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hyperacusis (disorder in loudness perception)
Photophobia (extreme sensitivity to light)
Overdose
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive

What are the existing conditions these people have? *

Hepatitis C: 7 people, 50.00%
Oropharyngeal Pain: 2 people, 14.29%
Fever: 2 people, 14.29%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 7.14%
Hiv Infection: 1 person, 7.14%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 1 person, 7.14%
Gastric Haemorrhage (bleeding stomach): 1 person, 7.14%
Dyspnea (difficult or laboured breathing): 1 person, 7.14%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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