Hc and Ketoconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Ketoconazole (ketoconazole). Common drug interactions include gastrointestinal disorder among females and hypothyroidism among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Ketoconazole. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

On Jul, 31, 2026

31 people who take Hc and Ketoconazole together, and have interactions are studied.

What are the common drug interactions of Hc and Ketoconazole, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Influenza
Irritable bowel syndrome
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neutropenia (an abnormally low number of neutrophils)
Oedema genital (fluid collection in tissue of genitals)
Renal failure acute (rapid kidney dysfunction)

male:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Diabetes mellitus non-insulin-dependent
Blood potassium increased
Dysstasia (difficulty in standing)
Hospitalisation
Weight decreased
Asthenia (weakness)
Denervation atrophy (interruption of the nerve connection to an organ waste away)
Difficulty in walking
Disease progression

What are the common drug interactions of Hc and Ketoconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Weakness
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Diabetes mellitus non-insulin-dependent
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Muscle spasms (muscle contraction)
Myopathy (a muscular disease in which the muscle fibres do not function)
Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Pain
Chronic kidney disease
Essential hypertension (primary hypertension)
Irritable bowel syndrome
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Renal cancer (cancer of kidney)
Sinus disorder (disease of sinus)
Tension headache
Vision blurred
Vitamin d deficiency

60+:

Bradycardia (abnormally slow heart action)
Renal failure acute (rapid kidney dysfunction)
Back pain
Chest discomfort
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Vertigo

What are the existing conditions these people have? *

Pain: 6 people, 19.35%
Ovarian Cancer (cancer of ovary): 4 people, 12.90%
Hyperkalemia (damage to or disease of the kidney): 4 people, 12.90%
High Blood Cholesterol: 3 people, 9.68%
Colon Cancer: 3 people, 9.68%
Insomnia (sleeplessness): 3 people, 9.68%
Weakness: 2 people, 6.45%
Bone Density Abnormal: 2 people, 6.45%
Depression: 2 people, 6.45%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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