Hc and Percocet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hc (hydrocortisone) and Percocet (acetaminophen; oxycodone hydrochloride). Common drug interactions include anaemia among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Hc and Percocet. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

On Jul, 10, 2026

55 people who take Hc and Percocet together, and have interactions are studied.

What are the common drug interactions of Hc and Percocet, by gender? *:

female:

Anaemia (lack of blood)
Chest discomfort
Chronic kidney disease
Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
Death
Dry eye (lack of adequate tears)
Gastritis (inflammation of stomach)
Haemorrhage (bleeding)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Renal disorder (kidney disease)

male:

Depression
Diarrhoea
Alternaria infection (infected by alternaria)
Anaemia (lack of blood)
Anorectal discomfort
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Hc and Percocet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)

20-29:

n/a

30-39:

Abdominal pain
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Constipation
Crying
Depressed mood
Diarrhoea
Disturbance in attention
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Headache (pain in head)

40-49:

Nasopharyngitis (inflammation of the nasopharynx)
Proctalgia (pain in the rectum)
Sleep disorder
Anorectal disorder
Attention deficit/hyperactivity disorder
Bipolar disorder (mood disorder)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Nephrogenic anaemia (anaemia due to kidney disease)
Breast cancer metastatic
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

Chest pain
Memory impairment
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Neck pain
Spinal osteoarthritis (joint cartilage loss in spine)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 9 people, 16.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.91%
Type 2 Diabetes: 5 people, 9.09%
Back Pain: 4 people, 7.27%
Depression: 4 people, 7.27%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 7.27%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 7.27%
Ovarian Cancer (cancer of ovary): 4 people, 7.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.27%
Insomnia (sleeplessness): 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

Do you take Hc and Percocet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously