Hectorol and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hectorol (doxercalciferol) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include gastritis erosive among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Hectorol and Hydramine. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Hectorol?

Hectorol has active ingredients of doxercalciferol. eHealthMe is studying from 1,815 Hectorol users. Check the latest studies of Hectorol.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 21, 2026

45 people who take Hectorol and Hydramine together, and have interactions are studied.

Hectorol and Hydramine drug interactions.

What are the common drug interactions of Hectorol and Hydramine, by gender? *:

female:

Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
High density lipoprotein
Hypercholesterolaemia (high levels of cholesterol in the blood)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Renal injury (kidney injury)
Anxiety
Arteriovenous fistula thrombosis (formation of a blood clot inside a blood vessel-av fistula)
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arteriosclerosis (thickening and hardening of arteries)
Back pain
Blood creatinine increased

What are the common drug interactions of Hectorol and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arteriovenous fistula occlusion
Diarrhoea
Focal segmental glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli)
Gastroenteritis (inflammation of stomach and intestine)
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Arteriovenous fistula thrombosis (formation of a blood clot inside a blood vessel-av fistula)
Graft loss (graft failure)
Thrombosis (formation of a blood clot inside a blood vessel)

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Alopecia (absence of hair from areas of the body)
Back pain
Drug hypersensitivity
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Pruritus (severe itching of the skin)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Anxiety
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood creatinine increased
Dyspnoea (difficult or laboured respiration)
Emotional distress
Glomerular filtration rate decreased

50-59:

Pruritus (severe itching of the skin)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Swelling
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vasculitis necrotising (inflammation and damage to blood vessels)
Vomiting
Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Accident
Activities of daily living impaired
Acute myocardial infarction (acute heart attack)
Acute respiratory failure
Alanine aminotransferase increased
Anaemia (lack of blood)
Anxiety

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 37.78%
High Blood Pressure: 14 people, 31.11%
High Blood Cholesterol: 8 people, 17.78%
Diabetes: 7 people, 15.56%
Stress And Anxiety: 6 people, 13.33%
Fever: 6 people, 13.33%
Pain: 6 people, 13.33%
Itching: 6 people, 13.33%
Blood Pressure Abnormal: 6 people, 13.33%
Infection: 6 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hectorol and Hydramine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously