Heparin sodium and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Heparin sodium (heparin sodium) and Hydroxyurea (hydroxyurea). Common drug interactions include cerebral atrophy among females and aplastic anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Heparin sodium and Hydroxyurea. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Heparin sodium?

Heparin sodium has active ingredients of heparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 21,065 Heparin sodium users. Check the latest studies of Heparin sodium.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

48 people who take Heparin sodium and Hydroxyurea together, and have interactions are studied.

Heparin sodium and Hydroxyurea drug interactions.

What are the common drug interactions of Heparin Sodium and Hydroxyurea, by gender? *:

female:

Cerebral atrophy (decrement in size of brain)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Disinhibition (loss of inhibition)
Feeling jittery
General physical health deterioration (weak health status)
Hyporeflexia (a condition of below normal or absent reflexes)
Hypoxia (low oxygen in tissues)
Hypoxic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)

male:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Diarrhoea
Confusional state
Constipation
Respiratory failure (inadequate gas exchange by the respiratory system)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Parkinson's disease
Aggression
Chest pain
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the common drug interactions of Heparin Sodium and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Insomnia (sleeplessness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Mucosal inflammation (infection of mucous membrane)
Pyrexia (fever)
Decreased appetite

20-29:

Haematoma (collection of blood outside the blood vessels)
Swelling
Wound dehiscence (a surgical incision reopens either internally or externally)

30-39:

Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Splenic infarction (tissue damage of spleen)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)

40-49:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hepatic failure (liver failure)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hyperglycaemia (high blood sugar)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)

50-59:

Abdominal pain
Acute respiratory failure
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Coagulopathy (blood's ability to clot is impaired)
Coma (state of unconsciousness lasting more than six hours)
Decreased appetite
Diarrhoea

60+:

Hallucination (an experience involving the perception of something not present)
Constipation
Dementia (madness)
Gait disturbance
Hallucination, visual (seeing things that aren't there)
Pain in extremity
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Skin ulcer
Atrioventricular block complete (heart block complete)

What are the existing conditions these people have? *

Pneumonia: 6 people, 12.50%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 12.50%
Thrombocytopenia (decrease of platelets in blood): 5 people, 10.42%
Parkinson's Disease: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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