Heparin and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Heparin (heparin sodium) and Caffeine (caffeine). Common drug interactions include infusion site oedema among females and thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Heparin and Caffeine. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

On Jul, 16, 2026

58 people who take Heparin and Caffeine together, and have interactions are studied.

What are the common drug interactions of Heparin and Caffeine, by gender? *:

female:

Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)
International normalised ratio increased
Intraventricular haemorrhage (intraventricular bleeding)
Oliguria (not enough urine)
Peripheral swelling
Platelet count decreased
Prealbumin decreased
Pregnancy
Pulmonary embolism (blockage of the main artery of the lung)
Rash

male:

Thrombosis (formation of a blood clot inside a blood vessel)
Drug hypersensitivity
Abdominal pain
Analgesic therapy
Appendicitis (inflammation of the appendix)
Ascites (accumulation of fluid in the abdominal cavity)
Bacterial infection
Blood cholesterol increased
Blood uric acid increased
Cardiogenic shock (inadequate circulation of blood)

What are the common drug interactions of Heparin and Caffeine, by age (0-1 to 60+)? *:

0-1:

Thrombosis (formation of a blood clot inside a blood vessel)
Device occlusion
Anaemia (lack of blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intraventricular haemorrhage (intraventricular bleeding)
Oliguria (not enough urine)
Platelet count decreased
General physical health deterioration (weak health status)
Hypozincaemia (the condition of having insufficient zinc in the body)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)

2-9:

n/a

10-19:

Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)
Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Constipation
Disease progression
Leukoencephalopathy (disease of the white matter in the brain)
Lip swelling
Septic shock (shock due to blood infection)

30-39:

Pregnancy
Pulmonary embolism (blockage of the main artery of the lung)
Anisocytosis (patient's red blood cells are of unequal size)
Blood glucose decreased
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hyperaesthesia
Hypertension (high blood pressure)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Drug abuse
Hepatic failure (liver failure)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Omphalitis (medical term for infection of the umbilical cord)
Pain
Pain in extremity
Peripheral swelling
Pneumonia
Post procedural complication
Post procedural infection
Pyrexia (fever)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sleep disorder

60+:

Abdominal pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cardiogenic shock (inadequate circulation of blood)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Dry mouth
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)

What are the existing conditions these people have? *

Pain: 9 people, 15.52%
Nausea (feeling of having an urge to vomit): 7 people, 12.07%
Diarrhea: 7 people, 12.07%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 7 people, 12.07%
Depression: 6 people, 10.34%
Apnoeic Attack: 6 people, 10.34%
Fever: 6 people, 10.34%
Constipation: 6 people, 10.34%
Stress And Anxiety: 6 people, 10.34%
Immunodeficiency Common Variable: 6 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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