Hetlioz and Rexulti drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hetlioz (tasimelteon) and Rexulti (brexpiprazole). Common drug interactions include insomnia among females and middle insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Hetlioz and Rexulti. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Hetlioz?

Hetlioz has active ingredients of tasimelteon. eHealthMe is studying from 7,418 Hetlioz users. Check the latest studies of Hetlioz.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

27 people who take Hetlioz and Rexulti together, and have interactions are studied.

What are the common drug interactions of Hetlioz and Rexulti, by gender? *:

female:

Insomnia (sleeplessness)
Nightmare (unpleasant dream)
Drug ineffective
Headache (pain in head)
Depression
Abdominal discomfort
Abnormal dreams
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Crying
Dizziness

male:

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Diarrhoea
Insomnia (sleeplessness)
Dysarthria (speech disorder)
Fall
Headache (pain in head)
Hypersensitivity
Limb injury
Nasopharyngitis (inflammation of the nasopharynx)
Renal disorder (kidney disease)

What are the common drug interactions of Hetlioz and Rexulti, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Nightmare (unpleasant dream)
Depression
Drug ineffective
Initial insomnia (feeling of inadequate or poor-quality sleep)
Insomnia (sleeplessness)

50-59:

Diarrhoea
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Tension headache
Drug ineffective

60+:

n/a

What are the existing conditions these people have? *

Blindness: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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