Hetlioz and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hetlioz (tasimelteon) and Sertraline (sertraline hydrochloride). Common drug interactions include sleep apnoea syndrome among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Hetlioz and Sertraline. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Hetlioz?

Hetlioz has active ingredients of tasimelteon. eHealthMe is studying from 7,418 Hetlioz users. Check the latest studies of Hetlioz.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

93 people who take Hetlioz and Sertraline together, and have interactions are studied.

Hetlioz and Sertraline drug interactions.

What are the common drug interactions of Hetlioz and Sertraline, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Surgery
Throat tightness
Weight increased
Insomnia (sleeplessness)
Drug ineffective
Somnolence (a state of near-sleep, a strong desire for sleep)
Sleep disorder
Abnormal dreams
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

male:

Insomnia (sleeplessness)
Oesophageal carcinoma (cancer tumour of oesophagus)
Nightmare (unpleasant dream)
Diarrhoea
Dysarthria (speech disorder)
Fall
Hypersensitivity
Ingrowing nail
Initial insomnia (feeling of inadequate or poor-quality sleep)
Intentional self-injury

What are the common drug interactions of Hetlioz and Sertraline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Decreased appetite
Insomnia (sleeplessness)
Aggression
Mood swings (an extreme or rapid change in mood)
Poor quality sleep
Affect lability (emotional incontinence)
Restless legs syndrome (a powerful urge to move your legs)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight decreased
White blood cell count decreased

50-59:

Drug ineffective
Headache (pain in head)
Abnormal dreams
Nocturia (the need to get up in the night to urinate)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Urinary tract infection
Abdominal discomfort
Choking sensation (feeling of obstruction in respiratory system)
Dyspepsia (indigestion)
Insomnia (sleeplessness)

60+:

Drug ineffective
Oesophageal carcinoma (cancer tumour of oesophagus)
Bladder discomfort
Blood pressure fluctuation
Cough
Dehydration (dryness resulting from the removal of water)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry mouth
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)

What are the existing conditions these people have? *

Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 26 people, 27.96%

* Approximation only. Some reports may have incomplete information.

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