Humalog and Opdivo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Humalog (insulin lispro recombinant) and Opdivo (nivolumab). Common drug interactions include gestational hypertension among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Humalog and Opdivo. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,127 Humalog users. Check the latest studies of Humalog.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

81 people who take Humalog and Opdivo together, and have interactions are studied.

What are the common drug interactions of Humalog and Opdivo, by gender? *:

female:

Gestational hypertension (elevated blood pressure during pregnancy)
Memory impairment
Rhinorrhoea (watery mucus discharge from the nose)
Urinary tract infection
Blood glucose increased
Adverse event
Arthropathy
Autoimmune hepatitis
Coma (state of unconsciousness lasting more than six hours)
Cough

male:

Diarrhoea
Death
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hypotension (abnormally low blood pressure)
Adverse event
Cerebral infarction (less blood supply to brain resulting tissue damage)
Decreased appetite
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Humalog and Opdivo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Cerebral infarction (less blood supply to brain resulting tissue damage)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Myositis (inflammation of the muscles)
Adverse event
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Malignant neoplasm progression (cancer tumour came back)
Oedema peripheral (superficial swelling)

50-59:

Diarrhoea
Altered state of consciousness (altered state of mind)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac flutter (abnormal heart rhythm)
Cerebral haemorrhage (bleeding within the brain)
Cough
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Hot flush (sudden feelings of heat)
Malaise (a feeling of general discomfort or uneasiness)

60+:

Death
Diarrhoea
Weight increased
Fatigue (feeling of tiredness)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Hypotension (abnormally low blood pressure)
Arthralgia (joint pain)
General physical health deterioration (weak health status)
Anaemia (lack of blood)
Blood glucose decreased

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 17 people, 20.99%
Malignant Melanoma (skin cancer rises from melancytes): 10 people, 12.35%
Malignant Melanoma Stage Iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started): 6 people, 7.41%
Type 2 Diabetes: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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