Humira and Eylea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Humira (adalimumab) and Eylea (aflibercept). Common drug interactions include discomfort among females and nephrolithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Humira and Eylea. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 761,396 Humira users. Check the latest studies of Humira.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

On Jul, 27, 2026

51 people who take Humira and Eylea together, and have interactions are studied.

What are the common drug interactions of Humira and Eylea, by gender? *:

female:

Discomfort
Fungal infection
Gastrointestinal motility disorder (abnormal intestinal contractions)
Headache (pain in head)
Joint swelling
Psoriasis (immune-mediated disease that affects the skin)
Rash
Renal impairment (severely reduced kidney function)
Visual impairment
Vision blurred

male:

Nephrolithiasis (calculi in the kidneys)
Visual impairment
Lung disorder (lung disease)
Productive cough
Retinal degeneration (death of the cells of the retina)
Skin maceration (process in which the skin is softened and broken down by extended exposure to wetness or moisture)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Weight decreased
Dysgraphia (impaired ability to learn to write)
Eye disorder

What are the common drug interactions of Humira and Eylea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cystoid macular oedema (fluid accumulation after cataract surgery)
Rebound effect (take-back effect)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Vision blurred
Congestive cardiomyopathy (weakening of heart muscle)
Eye haemorrhage (bleeding in the eye)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

40-49:

Oropharyngeal pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Throat irritation

50-59:

Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Blindness unilateral
Eye discharge
Fatigue (feeling of tiredness)
Photophobia (extreme sensitivity to light)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Staphylococcal infection (an infection with staphylococcus bacteria)
Ulcerative keratitis (ulcerative inflammation of the cornea)

60+:

Anaemia (lack of blood)
Cataract (clouding of the lens inside the eye)
Blindness unilateral
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Erythema (redness of the skin)
Large intestinal ulcer
Myalgia (muscle pain)
Myositis (inflammation of the muscles)
Oedema (fluid collection in tissue)

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 23.53%
High Blood Cholesterol: 8 people, 15.69%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 13.73%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 7 people, 13.73%
Sympathetic Ophthalmia (inflammatory condition affecting both eyes that occurs after a penetrating injury): 6 people, 11.76%
Prostatic Disorder: 5 people, 9.80%
Uveitis (inflammation of the uvea): 5 people, 9.80%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 9.80%
Retinal Degeneration (death of the cells of the retina): 5 people, 9.80%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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