Humira and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Humira (adalimumab) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include postoperative wound infection among females and nerve compression among males.

The phase IV clinical study analyzes what interactions people have when they take Humira and Synjardy. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 761,396 Humira users. Check the latest studies of Humira.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Jul, 14, 2026

32 people who take Humira and Synjardy together, and have interactions are studied.

What are the common drug interactions of Humira and Synjardy, by gender? *:

female:

Postoperative wound infection
Rash
Rectal haemorrhage (bleeding from anus)
Surgery
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thyroidectomy
Vertigo
Vomiting
Pain
Alopecia (absence of hair from areas of the body)

male:

Nerve compression
Mobility decreased (ability to move is reduced)
Pain in jaw
Peripheral swelling
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Spinal disorder (disease of spine a back bone)
Trismus (reduced opening of the jaws)
Weight increased
Drug ineffective
Dysstasia (difficulty in standing)

What are the common drug interactions of Humira and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site papule (solid pimple or swelling at injection site)

40-49:

Aortic dilatation
Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Photophobia (extreme sensitivity to light)
Vision blurred

50-59:

Blood thyroid stimulating hormone increased
Hypersensitivity
Pneumonia
Rhinorrhoea (watery mucus discharge from the nose)
Thyroid mass
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood iron decreased
Cold sweat
Dizziness

60+:

Blood glucose increased
Abdominal distension
Peripheral swelling
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Spinal disorder (disease of spine a back bone)
Trismus (reduced opening of the jaws)
Weight increased
Cataract (clouding of the lens inside the eye)
Arthralgia (joint pain)
Asthenia (weakness)

What are the existing conditions these people have? *

Diabetes: 12 people, 37.50%
High Blood Cholesterol: 9 people, 28.12%
High Blood Pressure: 6 people, 18.75%
Type 2 Diabetes: 5 people, 15.62%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 15.62%
Depression: 5 people, 15.62%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 12.50%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 9.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.38%
Pain: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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