Humulin n and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Humulin n (insulin susp isophane recombinant human) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include exostosis among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Humulin n and Hydramine. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Humulin n?

Humulin n has active ingredients of insulin susp isophane recombinant human. It is often used in diabetes. eHealthMe is studying from 9,878 Humulin n users. Check the latest studies of Humulin n.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.



On Jul, 09, 2026

65 people who take Humulin n and Hydramine together, and have interactions are studied.

Humulin n and Hydramine drug interactions.

What are the common drug interactions of Humulin N and Hydramine, by gender? *:

female:

  1. Exostosis (formation of new bone on the surface of a bone)
  2. Fall
  3. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  4. Headache (pain in head)
  5. Infusion site swelling
  6. Joint injury
  7. Kidney infection
  8. Renal cyst (kidney cyst)
  9. Weight increased
  10. Bladder disorder

male:

  1. Infusion related reaction
  2. Blood pressure increased
  3. Pain
  4. Pneumonia fungal
  5. Thrombocytopenia (decrease of platelets in blood)
  6. Transaminases increased
  7. Anxiety
  8. Arthralgia (joint pain)
  9. Bacterial infection
  10. Benign neoplasm (benign (non-cancerous) tumour)

What are the common drug interactions of Humulin N and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Nasopharyngitis (inflammation of the nasopharynx)

20-29:

n/a

30-39:

  1. Anaphylactic reaction (serious allergic reaction)
  2. Headache (pain in head)
  3. Hypersensitivity
  4. Pregnancy
  5. Rash pruritic (redness with itching)
  6. Weight increased

40-49:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Blood pressure increased
  4. Dry mouth
  5. Fatigue (feeling of tiredness)
  6. Heart rate increased
  7. Hyperhidrosis (abnormally increased sweating)
  8. Muscle spasms (muscle contraction)
  9. Muscular weakness (muscle weakness)
  10. Neurological symptom (symptoms of nervous system disease)

50-59:

  1. Obstructive airways disorder (a progressive disease that makes it hard to breathe)
  2. Oedema peripheral (superficial swelling)
  3. Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
  4. Post-traumatic stress disorder
  5. Pruritus (severe itching of the skin)
  6. Reflux nephropathy (when urine goes back up the wrong way from the bladder towards the kidney)
  7. Road traffic accident
  8. Sinus congestion (blockage of sinus)
  9. Staphylococcal infection (an infection with staphylococcus bacteria)
  10. Ulcer

60+:

  1. Neutropenia (an abnormally low number of neutrophils)
  2. Pneumonia fungal
  3. Blood creatinine increased
  4. Blood pressure decreased
  5. Dehydration (dryness resulting from the removal of water)
  6. Dysphonia (speech disorder attributable to a disorder of phonation)
  7. Febrile neutropenia (fever with reduced white blood cells)
  8. Gait disturbance
  9. Hypotension (abnormally low blood pressure)
  10. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 30 people, 46.15%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 15.38%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 10.77%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 9.23%
  5. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 7.69%
  6. Osteoporosis (bones weak and more likely to break): 4 people, 6.15%
  7. Nausea (feeling of having an urge to vomit): 4 people, 6.15%
  8. Constipation: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

Do you take Humulin n and Hydramine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Humulin n and Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Humulin n:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Humulin n and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydramine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on insulin susp isophane recombinant human and diphenhydramine hydrochloride (the active ingredients of Humulin n and Hydramine, respectively), and Humulin n and Hydramine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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