Hycamtin and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycamtin (topotecan hydrochloride) and Fentanyl (fentanyl citrate). Common drug interactions include depressed level of consciousness among females and neutrophil count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Hycamtin and Fentanyl. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Hycamtin?

Hycamtin has active ingredients of topotecan hydrochloride. eHealthMe is studying from 2,351 Hycamtin users. Check the latest studies of Hycamtin.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Jul, 26, 2026

20 people who take Hycamtin and Fentanyl together, and have interactions are studied.

Hycamtin and Fentanyl drug interactions.

What are the common drug interactions of Hycamtin and Fentanyl, by gender? *:

female:

Depressed level of consciousness
Somnolence (a state of near-sleep, a strong desire for sleep)
Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Respiratory distress (difficulty in breathing)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Cardiac arrest
Death
Disease progression

male:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Alanine aminotransferase increased
Haemoglobin decreased
Lymphocyte count increased
Platelet count decreased
Protein total decreased
Protein urine present
Red blood cell count decreased
Thrombocytopenia (decrease of platelets in blood)
Urobilin urine present

What are the common drug interactions of Hycamtin and Fentanyl, by age (0-1 to 60+)? *:

0-1:

Abdominal pain
Clostridial infection (infectious conditions by clostridium bacteria)
Conjunctivitis (pink eye)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Febrile neutropenia (fever with reduced white blood cells)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Penile ulceration

2-9:

n/a

10-19:

Hypoproteinaemia (too little prolactin circulating in the blood)

20-29:

n/a

30-39:

n/a

40-49:

Death
Neoplasm progression (growth of tumour)

50-59:

Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Respiratory distress (difficulty in breathing)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Haemoglobin decreased
White blood cell count decreased
Blood lactate dehydrogenase increased
Blood sodium decreased
Cardiac arrest
Depressed level of consciousness
Disease progression
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gamma-glutamyltransferase increased
Glucose urine present

What are the existing conditions these people have? *

Small Cell Lung Cancer Stage Unspecified (lung cancer in unknown stage): 5 people, 25.00%
Type 2 Diabetes: 1 person, 5.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 5.00%
Analgesic Effect: 1 person, 5.00%
Back Pain: 1 person, 5.00%
Cancer Pain: 1 person, 5.00%
Constipation: 1 person, 5.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.00%
Diabetes: 1 person, 5.00%
Diarrhea: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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