Hycodan and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include dysuria among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Bactrim. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Jul, 16, 2026

30 people who take Hycodan and Bactrim together, and have interactions are studied.

What are the common drug interactions of Hycodan and Bactrim, by gender? *:

female:

Dysuria (painful or difficult urination)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lung disorder (lung disease)
Lung infection
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Presyncope
Rales (an abnormal respiratory sound characterized by fine crackles)
Rash generalised (rash on most of body parts)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Pyrexia (fever)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Post-operative haemorrhage (post-operative bleeding)
Anaemia (lack of blood)
Asthma
Blood creatinine increased
Chest tightness
Dyspnoea (difficult or laboured respiration)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemosiderosis (general increase in tissue iron stores without associated tissue damage)

What are the common drug interactions of Hycodan and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood bilirubin increased
Haematocrit decreased
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
Post-operative haemorrhage (post-operative bleeding)
Pyrexia (fever)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemosiderosis (general increase in tissue iron stores without associated tissue damage)
Hepatitis (inflammation of the liver)

30-39:

Asthma
Blood creatinine increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest tightness
Dyspnoea (difficult or laboured respiration)
Loin pain (pain originates from kidney)
Lung disorder (lung disease)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Pyrexia (fever)

40-49:

n/a

50-59:

Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clumsiness (a lack of coordination or elegance)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Erectile dysfunction
Fall
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)

60+:

Dyspnoea (difficult or laboured respiration)
Dizziness postural
Rash generalised (rash on most of body parts)
Syncope (loss of consciousness with an inability to maintain postural tone)
Wheezing (a high-pitched whistling sound made while you breath)
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Nausea (feeling of having an urge to vomit)
Pneumonia
Vaginal cancer

What are the existing conditions these people have? *

Pain: 4 people, 13.33%
Vaginal Tumors: 3 people, 10.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.67%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 6.67%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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