Hycodan and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Compazine (prochlorperazine maleate). Common drug interactions include death among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Compazine. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 21, 2026

13 people who take Hycodan and Compazine together, and have interactions are studied.

Hycodan and Compazine drug interactions.

What are the common drug interactions of Hycodan and Compazine, by gender? *:

female:

Death
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Pulmonary embolism (blockage of the main artery of the lung)
Adverse event
Thrombocytopenia (decrease of platelets in blood)

male:

Death
Arthralgia (joint pain)
Pneumonia
Bone pain
Chills (felling of cold)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Discomfort
Gait disturbance
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Hycodan and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Adverse event

40-49:

n/a

50-59:

Chest pain
Pneumonia
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)

60+:

Dyspnoea (difficult or laboured respiration)
Death
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Chest pain
Diarrhoea
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Haemophilus infection (bacterial infection by haemophilus influenzae)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 30.77%
Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 30.77%
Pain: 3 people, 23.08%
Diarrhea: 3 people, 23.08%
Constipation: 2 people, 15.38%
Insomnia (sleeplessness): 2 people, 15.38%
Depression: 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
Gastritis (inflammation of stomach): 1 person, 7.69%
Dizziness: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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