Hycodan and Demerol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Demerol (meperidine hydrochloride). Common drug interactions include abdominal pain among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Demerol. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Demerol?

Demerol has active ingredients of meperidine hydrochloride. It is often used in pain. eHealthMe is studying from 12,706 Demerol users. Check the latest studies of Demerol.

On Aug, 11, 2026

23 people who take Hycodan and Demerol together, and have interactions are studied.

What are the common drug interactions of Hycodan and Demerol, by gender? *:

female:

Abdominal pain
Back pain
Depression
Drug abuse
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Pleural effusion (water on the lungs)
Rash pruritic (redness with itching)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)

male:

Abdominal discomfort
Actinomyces test positive
Bone marrow failure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cachexia (loss of weight)
Catheter related infection
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)
Cerebral artery stenosis (hardening of brain blood vessels)

What are the common drug interactions of Hycodan and Demerol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hodgkin's disease (cancer originating from white blood cells)
Impetigo (contagious skin infection)
Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears)
Lacrimation increased
Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neuropathy peripheral (surface nerve damage)
Oral herpes (viral infection of mouth)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)

30-39:

Adjustment disorder
Brain neoplasm (tumour of brain)
Candidiasis (candidiasis or thrush is a fungal infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Dependent personality disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Dysthymic disorder (mild chronic depression disorder)
Dysuria (painful or difficult urination)

40-49:

Drug ineffective
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Restlessness (not able to rest)
Sleep disorder
Suicide attempt
Urinary retention (the inability to completely or partially empty the bladder)
Catheter related infection
Staphylococcal bacteraemia (a bacterial infection of blood)
Swelling

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Vascular calcification (deposits of calcium in the blood vessels)
Vertigo positional
Vomiting
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Upper respiratory tract infection
Abdominal pain
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Cellulitis (infection under the skin)

60+:

Drug hypersensitivity
Bone marrow failure
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Klebsiella infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Urinary tract infection

What are the existing conditions these people have? *

Oropharyngeal Pain: 6 people, 26.09%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 26.09%
Migraine (headache): 4 people, 17.39%
Headache (pain in head): 4 people, 17.39%
Stress And Anxiety: 3 people, 13.04%
Insomnia (sleeplessness): 3 people, 13.04%
Pain In Extremity: 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Breakthrough Pain: 2 people, 8.70%
Back Pain: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Hycodan and Demerol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously