Hycodan and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate) and Singulair (montelukast sodium). Common drug interactions include lymphadenopathy among females and disorientation among males.

The phase IV clinical study analyzes what interactions people have when they take Hycodan and Singulair. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

On Jul, 06, 2026

47 people who take Hycodan and Singulair together, and have interactions are studied.

Hycodan and Singulair drug interactions.

What are the common drug interactions of Hycodan and Singulair, by gender? *:

female:

Lymphadenopathy (disease or enlargement of lymph nodes)
Neuropathy peripheral (surface nerve damage)
Oral herpes (viral infection of mouth)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Synovial cyst (cyst of joint filled with synovial fluid)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Adnexa uteri mass (ovarian cysts)

male:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Abdominal discomfort
Actinomyces test positive
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)

What are the common drug interactions of Hycodan and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)
Hodgkin's disease (cancer originating from white blood cells)
Impetigo (contagious skin infection)
Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears)
Lacrimation increased
Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Neuropathy peripheral (surface nerve damage)
Oral herpes (viral infection of mouth)
Palpitations (feelings or sensations that your heart is pounding or racing)

30-39:

Adjustment disorder
Brain neoplasm (tumour of brain)
Candidiasis (candidiasis or thrush is a fungal infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Dependent personality disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Dysthymic disorder (mild chronic depression disorder)
Dysuria (painful or difficult urination)

40-49:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Pancreatitis (inflammation of pancreas)
Back pain
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Femoral neck fracture (neck of femur bone fracture)
Groin pain
Hospitalisation
Influenza
Muscle spasms (muscle contraction)

50-59:

Arrhythmia (irregular heartbeat)
Arteriosclerosis (thickening and hardening of arteries)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)
Back pain
Balanitis candida (inflammation of the glands penis by infection with candida albicans)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)

60+:

Sudden death
Pyrexia (fever)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Increased appetite
Infection
Infusion site haematoma (localized swelling filled with blood at infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Joint swelling

What are the existing conditions these people have? *

Pain: 11 people, 23.40%
Oropharyngeal Pain: 7 people, 14.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.77%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 12.77%
Stress And Anxiety: 5 people, 10.64%
Renal Cell Carcinoma (a kidney cancer): 5 people, 10.64%
Nausea (feeling of having an urge to vomit): 5 people, 10.64%
High Blood Cholesterol: 5 people, 10.64%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 8.51%
Type 2 Diabetes: 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

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