Hydramine and Atomoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Atomoxetine (atomoxetine). Common drug interactions include psoriatic arthropathy among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Atomoxetine. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Atomoxetine?

Atomoxetine has active ingredients of atomoxetine. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,363 Atomoxetine users. Check the latest studies of Atomoxetine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

72 people who take Hydramine and Atomoxetine together, and have interactions are studied.

Hydramine and Atomoxetine drug interactions.

What are the common drug interactions of Hydramine and Atomoxetine, by gender? *:

female:

Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory depression (respiration has a rate below 12 breaths)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Scar
Seasonal allergy (allergic condition due to certain season)
Sinusitis (inflammation of sinus)
Swelling
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Completed suicide (act of taking one's own life)

male:

Completed suicide (act of taking one's own life)
Cardiac arrest
Irritability
Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Gastric varices
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)

What are the common drug interactions of Hydramine and Atomoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Overdose
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac arrest
Completed suicide (act of taking one's own life)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Liver injury
Myocarditis (inflammation of heart muscle myocardium)
Dizziness
Electrocardiogram qt prolonged
Headache (pain in head)

20-29:

Completed suicide (act of taking one's own life)
Cardiac arrest
Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hypotension (abnormally low blood pressure)
Somnolence (a state of near-sleep, a strong desire for sleep)
Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)

30-39:

n/a

40-49:

Ear pain
Fatigue (feeling of tiredness)
Feeling jittery
Headache (pain in head)
Infusion related reaction
Poor venous access
Rhinorrhoea (watery mucus discharge from the nose)
Muscular weakness (muscle weakness)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Blepharitis (chronic inflammation of the eyelid)
Eye infection
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Eyelid infection
Staphylococcal infection (an infection with staphylococcus bacteria)
Fall
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Weight decreased
Infection

60+:

n/a

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 18.06%
Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 6.94%
Rickets (softening of bones): 5 people, 6.94%
Itching: 5 people, 6.94%
Autoimmune Hepatitis: 5 people, 6.94%
Viral Skin Infection: 4 people, 5.56%
Sleep Disorder: 4 people, 5.56%
Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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