Hydramine and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include headache among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Avalide. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Aug, 02, 2026

50 people who take Hydramine and Avalide together, and have interactions are studied.

Hydramine and Avalide drug interactions.

What are the common drug interactions of Hydramine and Avalide, by gender? *:

female:

Headache (pain in head)
Lymphoedema (localized fluid retention and tissue swelling)
Malaise (a feeling of general discomfort or uneasiness)
Metastases to central nervous system (cancer spreads to central nervous system)
Mucosal inflammation (infection of mucous membrane)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Night sweats (sweating in night)
Oedema peripheral (superficial swelling)
Osteonecrosis (death of bone)
Ovarian cancer (cancer of ovary)

male:

Pain
Arteriosclerosis (thickening and hardening of arteries)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Conjunctivitis (pink eye)
Death
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyskinesia (abnormality or impairment of voluntary movement)
Erectile dysfunction
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)

What are the common drug interactions of Hydramine and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Neuropathy peripheral (surface nerve damage)
Type 1 diabetes mellitus
Type 2 diabetes mellitus

40-49:

Abdominal pain
Anaemia (lack of blood)
Colonoscopy
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dysarthria (speech disorder)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Gastroenteritis (inflammation of stomach and intestine)
Haematuria (presence of blood in urine)

50-59:

Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Dizziness
Drug hypersensitivity
Lower respiratory tract infection
Renal failure (kidney dysfunction)
Weight decreased

60+:

Pneumonia
Arteriosclerosis (thickening and hardening of arteries)
Mucosal inflammation (infection of mucous membrane)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Ovarian cancer (cancer of ovary)
Pericardial effusion (fluid around the heart)
Renal failure (kidney dysfunction)
Stomatitis (inflammation of mucous membrane of mouth)
Thrombocytopenia (decrease of platelets in blood)
Atrioventricular block first degree (heart block first degree)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 25 people, 50.00%
Multiple Myeloma (cancer of the plasma cells): 5 people, 10.00%
Metastases To Bone (cancer spreads to bone): 3 people, 6.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.00%
Diabetes: 3 people, 6.00%
Breast Cancer Metastatic: 3 people, 6.00%
Breast Cancer: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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