Hydramine and Cefaclor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Cefaclor (cefaclor). Common drug interactions include parotitis among females and white blood cell count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Cefaclor. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Cefaclor?

Cefaclor has active ingredients of cefaclor. eHealthMe is studying from 2,512 Cefaclor users. Check the latest studies of Cefaclor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

59 people who take Hydramine and Cefaclor together, and have interactions are studied.

Hydramine and Cefaclor drug interactions.

What are the common drug interactions of Hydramine and Cefaclor, by gender? *:

female:

Parotitis (inflammation of a parotid gland)
Portal hypertensive gastropathy (changes in the mucosa of the stomach in patients with portal hypertension;)
Renal impairment (severely reduced kidney function)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Injection site pain
Ligament sprain (ligament stretched)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Renal failure (kidney dysfunction)
Respiratory tract infection
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

male:

White blood cell count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Diarrhoea
Anaemia (lack of blood)
Constipation
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Infusion related reaction
Pyrexia (fever)
Urinary tract infection
Blood urine present

What are the common drug interactions of Hydramine and Cefaclor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Skeletal injury (bone and supporting muscle injury)
Sleep talking (talking during sleeping)
Somnambulism (sleep walking)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tendon injury
Tendonitis (a condition that causes pain and swelling of tendons)
Weight increased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cellulitis (infection under the skin)
Chest pain

50-59:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased
Anaemia (lack of blood)
Hypokalaemia (low potassium)
Hypoproteinaemia (too little prolactin circulating in the blood)
Haematuria (presence of blood in urine)
Hydronephrosis (water inside the kidney)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

60+:

White blood cell count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema peripheral (superficial swelling)
Constipation
Diarrhoea
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Pain
Pyrexia (fever)

What are the existing conditions these people have? *

Pain: 18 people, 30.51%
Cough: 11 people, 18.64%
High Blood Pressure: 11 people, 18.64%
Urination - Excessive Volume: 9 people, 15.25%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 15.25%
Urinary Tract Infection: 9 people, 15.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 13.56%
Depression: 7 people, 11.86%
Primary Immunodeficiency Syndrome: 7 people, 11.86%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 11.86%

* Approximation only. Some reports may have incomplete information.

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