Hydramine and Dexrazoxane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Dexrazoxane (dexrazoxane hydrochloride). Common drug interactions include chest discomfort among females and pathological fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Dexrazoxane. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Dexrazoxane?

Dexrazoxane has active ingredients of dexrazoxane hydrochloride. eHealthMe is studying from 1,141 Dexrazoxane users. Check the latest studies of Dexrazoxane.

On Jul, 10, 2026

56 people who take Hydramine and Dexrazoxane together, and have interactions are studied.

Hydramine and Dexrazoxane drug interactions.

What are the common drug interactions of Hydramine and Dexrazoxane, by gender? *:

female:

Chest discomfort
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Uterine haemorrhage (uterine bleeding)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Hypertriglyceridaemia (excess of triglycerides in the blood)
Optic nerve disorder (disease of optic nerve)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

male:

Pathological fracture (broken bone caused by disease)
Febrile neutropenia (fever with reduced white blood cells)
Cardiotoxicity (damage to the heart muscle)
Cough
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aphasia (damage to the parts of the brain that control language)
Bradycardia (abnormally slow heart action)
Chills (felling of cold)

What are the common drug interactions of Hydramine and Dexrazoxane, by age (0-1 to 60+)? *:

0-1:

Bradycardia (abnormally slow heart action)
Chills (felling of cold)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypotension (abnormally low blood pressure)
Pyrexia (fever)

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Aphasia (damage to the parts of the brain that control language)
Depressed level of consciousness
Excessive eye blinking (excessive blinking is dry eyes)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Staring (a prolonged gaze or fixed look)
Unresponsive to stimuli
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Venoocclusive disease (small veins in the liver are obstructed)

10-19:

Sepsis (a severe blood infection that can lead to organ failure and death)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Hypertriglyceridaemia (excess of triglycerides in the blood)
Optic nerve disorder (disease of optic nerve)
Decreased appetite
Nausea (feeling of having an urge to vomit)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Blastomycosis (fungal infection caused by fungus blastomyces dermatitidis)

20-29:

Bacteraemia (presence of bacteria in the blood)
Decreased appetite
Dysphagia (a condition in which swallowing is difficult or painful)
Epistaxis (bleed from the nose)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Peripheral nerve injury
Peroneal nerve injury
Upper respiratory tract infection
Vomiting

30-39:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Lip discolouration
Skin discolouration (change of skin colour)
Vomiting
Alopecia (absence of hair from areas of the body)
Anxiety
Areflexia (absence of a reflex)

40-49:

Uterine haemorrhage (uterine bleeding)
Febrile neutropenia (fever with reduced white blood cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)

50-59:

Chest discomfort
Fatigue (feeling of tiredness)
Oral mucosal blistering (mouth ulcer)
Oral pain
Osteonecrosis (death of bone)
Tooth extraction

60+:

Pathological fracture (broken bone caused by disease)
Febrile neutropenia (fever with reduced white blood cells)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Bacteraemia (presence of bacteria in the blood)
Constipation
Diarrhoea
Dry throat
Dyspnoea exertional (breathlessness or shortness of breath)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Leukopenia (less number of white blood cells in blood)

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 22 people, 39.29%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 14.29%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 12.50%
Urination - Excessive Volume: 4 people, 7.14%
Allergies: 4 people, 7.14%
Nausea And Vomiting: 3 people, 5.36%
Hypotension (abnormally low blood pressure): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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