Hydramine and Diamox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Diamox (acetazolamide). Common drug interactions include histiocytosis haematophagic among females and enterocolitis among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Diamox. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Diamox?

Diamox has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 4,711 Diamox users. Check the latest studies of Diamox.

On Jul, 17, 2026

30 people who take Hydramine and Diamox together, and have interactions are studied.

What are the common drug interactions of Hydramine and Diamox, by gender? *:

female:

Histiocytosis haematophagic
Influenza
Influenza like illness
Infusion site pain
Intestinal perforation (complete penetration of the wall of the intestine)
Intraventricular haemorrhage (intraventricular bleeding)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)
Headache (pain in head)
Vomiting
Hypotension (abnormally low blood pressure)

male:

Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Altered state of consciousness (altered state of mind)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Hydramine and Diamox, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

Altered state of consciousness (altered state of mind)
Hydrocephalus (water on the brain)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)

10-19:

Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Papilloedema (optic disc swelling)
Pruritus (severe itching of the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retinal disorder (disease of retina)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vision blurred
Visual impairment
Aortic valve stenosis (narrowing of the aortic valve)
Back pain

20-29:

Arthralgia (joint pain)
Pyrexia (fever)
Abdominal discomfort
Body temperature increased
Bone pain
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Headache (pain in head)

30-39:

Headache (pain in head)
Influenza
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Vomiting

40-49:

Headache (pain in head)
Asthma
Blood pressure decreased
Cardiac disorder
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hypersensitivity
Hypotension (abnormally low blood pressure)
Infusion related reaction
Loss of consciousness
Lower limb fracture

50-59:

Hospitalisation
Neoplasm (tumour)

60+:

Cardiac failure congestive
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Heart rate irregular
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypokalaemia (low potassium)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Liver disorder (liver diseases)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Parotid gland enlargement
Proteinuria (presence of protein in the urine)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 20.00%
Constipation: 3 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.67%
Stomatitis (inflammation of mucous membrane of mouth): 2 people, 6.67%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 6.67%
Pneumonia: 2 people, 6.67%
Gastrointestinal Infection (infection of stomach and intestine): 2 people, 6.67%
Gastritis - Chronic (long lasting inflammation of stomach): 2 people, 6.67%
Fever: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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