Hydramine and Monurol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Monurol (fosfomycin tromethamine). Common drug interactions include malaise among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Monurol. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Monurol?

Monurol has active ingredients of fosfomycin tromethamine. eHealthMe is studying from 710 Monurol users. Check the latest studies of Monurol.



On Jul, 13, 2026

54 people who take Hydramine and Monurol together, and have interactions are studied.

Hydramine and Monurol drug interactions.

What are the common drug interactions of Hydramine and Monurol, by gender? *:

female:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Fatigue (feeling of tiredness)
  3. Headache (pain in head)
  4. Kidney infection
  5. Urinary tract infection
  6. Infusion site erythema (reddening of the skin at infusion site)
  7. Asthenia (weakness)
  8. Cystitis (inflammation of the wall of the bladder)
  9. Dizziness
  10. Seasonal allergy (allergic condition due to certain season)

male:

  1. Fatigue (feeling of tiredness)
  2. Headache (pain in head)
  3. Surgery
  4. Chronic kidney disease
  5. Death
  6. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  9. Renal failure (kidney dysfunction)
  10. Infusion related reaction

What are the common drug interactions of Hydramine and Monurol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Pain
  2. Pneumonia
  3. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  4. Urinary tract infection
  5. Infection
  6. Respiratory tract infection
  7. Surgery
  8. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  9. Chills (felling of cold)
  10. Fatigue (feeling of tiredness)

30-39:

n/a

40-49:

  1. Infusion site erythema (reddening of the skin at infusion site)
  2. Infusion site pruritus (severe itching at infusion site)
  3. Infusion site urticaria (rash of round, red welts on the skin at infusion site)

50-59:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Kidney infection
  3. Fatigue (feeling of tiredness)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Pain in extremity
  6. Sepsis (a severe blood infection that can lead to organ failure and death)
  7. Sinusitis (inflammation of sinus)
  8. Urinary tract infection
  9. Depression
  10. Pruritus (severe itching of the skin)

60+:

  1. Asthenia (weakness)
  2. Back pain
  3. Dehydration (dryness resulting from the removal of water)
  4. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  5. Nephrogenic anaemia (anaemia due to kidney disease)
  6. Pneumonia
  7. Renal failure (kidney dysfunction)
  8. Fatigue (feeling of tiredness)
  9. Headache (pain in head)
  10. Infusion related reaction

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 36 people, 66.67%
  2. Immunodeficiency: 15 people, 27.78%
  3. Primary Immunodeficiency Syndrome: 13 people, 24.07%
  4. Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 9 people, 16.67%
  5. Bacterial Infection: 7 people, 12.96%
  6. Renal Disorder (kidney disease): 4 people, 7.41%
  7. Sle Arthritis (an autoimmune disease that causes your immune system to attack your body's own joints): 3 people, 5.56%
  8. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and Monurol?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydramine and Monurol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Monurol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydramine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Monurol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and fosfomycin tromethamine (the active ingredients of Hydramine and Monurol, respectively), and Hydramine and Monurol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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