Hydramine and Myozyme drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Myozyme (alglucosidase alfa). Common drug interactions include lethargy among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Myozyme. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Myozyme?

Myozyme has active ingredients of alglucosidase alfa. eHealthMe is studying from 3,121 Myozyme users. Check the latest studies of Myozyme.

On Jul, 13, 2026

32 people who take Hydramine and Myozyme together, and have interactions are studied.

Hydramine and Myozyme drug interactions.

What are the common drug interactions of Hydramine and Myozyme, by gender? *:

female:

Lethargy (tiredness)
Speech disorder
Vomiting
Hypersensitivity
Flushing (the warm, red condition of human skin)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Abdominal discomfort
Accident
Agitation (state of anxiety or nervous excitement)
Alopecia (absence of hair from areas of the body)

male:

Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Infection
Respiratory distress (difficulty in breathing)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Diaphragm muscle weakness
Foot fracture
Forearm fracture (fracture in between wrist to elbow)
Hypoacusis (loss of hearing)
Joint contracture (a permanent shortening of a muscle or joint)

What are the common drug interactions of Hydramine and Myozyme, by age (0-1 to 60+)? *:

0-1:

Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Respiratory rate increased (excess breathing rate/min)
Infection
Respiratory distress (difficulty in breathing)
Wheezing (a high-pitched whistling sound made while you breath)
Blood magnesium increased
Blood pressure decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

2-9:

Pneumonia
Precocious puberty
Respiratory disorder (respiratory disease)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract)
Angioedema (rapid swelling of the dermis)
Arthralgia (joint pain)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dysgeusia (disorder of the sense of taste)
Epistaxis (bleed from the nose)

10-19:

Abdominal pain
Dizziness
Nausea (feeling of having an urge to vomit)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

20-29:

n/a

30-39:

Fall
Gait disturbance
Muscular weakness (muscle weakness)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Respiratory distress (difficulty in breathing)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Jessner's lymphocytic infiltration (collections of lymphocytes, macrophages, and dendritic cells in the skin)
Drug hypersensitivity
Gait disturbance
Lethargy (tiredness)
Speech disorder
Hypersensitivity

50-59:

Chest discomfort
Fluid retention (an abnormal accumulation of fluid in the blood)
Joint swelling
Loss of consciousness
Peripheral swelling
Pyrexia (fever)
Retching (strong involuntary effort to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vision blurred

60+:

n/a

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 3 people, 9.38%
Drug Hypersensitivity: 3 people, 9.38%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.25%
Pain: 2 people, 6.25%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 6.25%
Cervical Spinal Stenosis (narrowing of the spinal canal in the neck): 2 people, 6.25%
Acne (skin problems that cause pimples): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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