Hydramine and Paxlovid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Paxlovid (nirmatrelvir; ritonavir). Common drug interactions include eye irritation among females and disease recurrence among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Paxlovid. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,421 Paxlovid users. Check the latest studies of Paxlovid.

On Jul, 18, 2026

85 people who take Hydramine and Paxlovid together, and have interactions are studied.

Hydramine and Paxlovid drug interactions.

What are the common drug interactions of Hydramine and Paxlovid, by gender? *:

female:

Eye irritation
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infusion related reaction
Abdominal pain
Anaemia (lack of blood)
Blood glucose increased
Bone marrow disorder
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

male:

Disease recurrence
Pyrexia (fever)
Tinnitus (a ringing in the ears)
Arthralgia (joint pain)
Asthma
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear infection
Femur fracture
Haematocrit decreased

What are the common drug interactions of Hydramine and Paxlovid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug level below therapeutic
Salivary hypersecretion (excess saliva secretion)

30-39:

Pyrexia (fever)
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Feeling hot
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)
Nasopharyngitis (inflammation of the nasopharynx)
Sinus congestion (blockage of sinus)

40-49:

Aphonia (inability to produce voice)
Disease recurrence
Epistaxis (bleed from the nose)
Headache (pain in head)
Infusion related reaction
Pleural effusion (water on the lungs)
Pneumonia
Pruritus (severe itching of the skin)

50-59:

Lower respiratory tract infection
Oral infection
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Tenderness (pain or discomfort when an affected area is touched)
Upper respiratory tract infection
Urinary tract infection
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Conjunctivitis (pink eye)
Dysgeusia (disorder of the sense of taste)

60+:

Headache (pain in head)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Migraine (headache)
Blood pressure systolic increased
Disease recurrence
Dyspnoea exertional (breathlessness or shortness of breath)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinus congestion (blockage of sinus)
Urinary tract infection
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 21 people, 24.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 8.24%
Upper-Airway Cough Syndrome: 5 people, 5.88%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 5.88%
Asthma: 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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