Hydramine and Peppermint oil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Peppermint oil (peppermint). Common drug interactions include skin ulcer among females and loss of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Peppermint oil. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Peppermint oil?

Peppermint oil has active ingredients of peppermint. eHealthMe is studying from 1,061 Peppermint oil users. Check the latest studies of Peppermint oil.

On Jul, 25, 2026

52 people who take Hydramine and Peppermint oil together, and have interactions are studied.

Hydramine and Peppermint oil drug interactions.

What are the common drug interactions of Hydramine and Peppermint Oil, by gender? *:

female:

Skin ulcer
Stomatitis (inflammation of mucous membrane of mouth)
Stress
Vaginal discharge
Vaginal haemorrhage (vaginal bleeding)
Vaginal infection
Sinusitis (inflammation of sinus)
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)

male:

Loss of consciousness
Agitation (state of anxiety or nervous excitement)
Head discomfort
Headache (pain in head)
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Sneezing
Tachyphrenia (abnormally rapid mental activity)

What are the common drug interactions of Hydramine and Peppermint Oil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fungal infection
Hypersensitivity
Upper respiratory tract infection

30-39:

Ear infection
Sinusitis (inflammation of sinus)

40-49:

Agitation (state of anxiety or nervous excitement)
Anxiety
Diarrhoea
Energy increased
Feeling hot
Head discomfort
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)
Sneezing
Stomatitis (inflammation of mucous membrane of mouth)

50-59:

Localised infection (infection at the single location)
Migraine (headache)
Oral infection
Sinus disorder (disease of sinus)
Stomatitis (inflammation of mucous membrane of mouth)
Tenderness (pain or discomfort when an affected area is touched)
Upper respiratory tract infection
Abdominal pain
Back pain
Sinusitis (inflammation of sinus)

60+:

Bacterial infection
Constipation
Pain in extremity
Rash erythematous (redness of the skin)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cataract (clouding of the lens inside the eye)
Fall
Infusion site pruritus (severe itching at infusion site)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pneumonia

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 34 people, 65.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 11.54%
Pain: 4 people, 7.69%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 7.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 3 people, 5.77%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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