Hydramine and Sodium ascorbate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Sodium ascorbate (vitamin c (ascorbic acid)). Common drug interactions include constipation among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Sodium ascorbate. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Sodium ascorbate?

Sodium ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 321 Sodium ascorbate users. Check the latest studies of Sodium ascorbate.

On Aug, 12, 2026

58 people who take Hydramine and Sodium ascorbate together, and have interactions are studied.

Hydramine and Sodium ascorbate drug interactions.

What are the common drug interactions of Hydramine and Sodium Ascorbate, by gender? *:

female:

Constipation
Erythema (redness of the skin)
Drug ineffective
Infusion related reaction
Pyrexia (fever)
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Asthma
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

male:

Drug dependence
Respiratory depression (respiration has a rate below 12 breaths)
Victim of child abuse
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Gastrointestinal infection (infection of stomach and intestine)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Hydramine and Sodium Ascorbate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug dependence
Respiratory depression (respiration has a rate below 12 breaths)
Victim of child abuse

20-29:

n/a

30-39:

Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection
Asthma
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Coeliac disease (simple food intolerance)
Constipation
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)

40-49:

n/a

50-59:

Asthma
Back pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Coeliac disease (simple food intolerance)
Constipation
Drug hypersensitivity
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Food allergy

60+:

Abdominal pain
Pain
Procedural pain
Pyrexia (fever)
Weight decreased
Anaemia (lack of blood)
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Erythema (redness of the skin)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 33 people, 56.90%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 31 people, 53.45%
Herpes Zoster: 20 people, 34.48%
Pain: 19 people, 32.76%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 16 people, 27.59%
Allergies: 13 people, 22.41%
Asthma: 12 people, 20.69%
Nausea (feeling of having an urge to vomit): 9 people, 15.52%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 8.62%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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